Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1996-12-19
1998-06-09
Huff, Sheela
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 2, 435 71, 435 72, 435 721, 435 29, 435325, 435366, 435372, 435374, 436821, 604 7, C12Q 100, C12Q 102, G01N 3353, G01N 33567
Patent
active
057631565
ABSTRACT:
A composition and methods for use thereof relating to polypeptides having the ability to act as an inhibitor of complement C5b-9 complex activity. The compositions contain an 18 kDa protein found on the surface of human erythrocytes, a 37 kDa protein found on the surface of human platelets, a 37 kDa protein found on the surface of human endothelial cells, active derivatives or fragments thereof which act to inhibit the activity of C5b-9, anti-idiotypic antibodies mimicking the action of the inhibitor proteins or antibodies against C7 or C9 which block the formation of the C5b-9 complex. The compositions can be used in vitro to inhibit C5b-9 related stimulatory responses of platelets and vascular endothelium of perfused organs and tissues, thereby preventing the C5b-9 initiated cell necrosis or stimulated secretion of proteolytic enzymes and the exposure of the procoagulant membrane receptors during collection and in vitro storage. Further, immune disease states can be treated by administering an effective amount of a C5b-9 inhibitor to suppress C5b-9 mediated platelet activation in vivo.
REFERENCES:
patent: 4762701 (1988-08-01), Horan et al.
Sims et al J. Biol. Chem. vol. 263 p. 18105, Dec. 1988.
Sims et al, Biochemistry vol. 13 p. 3315, 1974.
Sims Peter J.
Wiedmer Therese
Huff Sheela
Oklahoma Medical Research
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