Inhibition of complement mediated inflammatory response

Details Inhibition of complement mediated inflammatory response Inhibition of complement mediated inflammatory response

1994-05-16

1996-08-27

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 514 12, 530350, 530380, 530830, C07K 1500, A61K 3702, A61K 3764

Patent

active

055501087

ABSTRACT:
A composition and methods for use thereof relating to polypeptides having the ability to act as an inhibitor of complement C5b-9 complex activity. The compositions contain an 18 kDa protein found on the surface of human erythrocytes, active derivatives or fragments thereof which act to inhibit the activity of C5b-9, anti-idiotypic antibodies mimicking the action of the inhibitor proteins or antibodies against C7 or C9 which block the formation of the C5b-9 complex. The compositions can be used in vitro to inhibit C5b-9 related stimulatory responses of platelets and vascular endothelium of perfused organs and tissues, thereby preventing the C5b-9 initiated cell necrosis or stimulated secretion of proteolytic enzymes and the exposure of the procoagulant membrane receptors during collection and in vitro storage. Further, immune disease states can be treated by administering an effective amount of a C5b-9 inhibitor to suppress C5b-9 mediated platelet activation in vivo.

REFERENCES:
patent: 4447415 (1984-05-01), Rock et al.
patent: 4695460 (1989-09-01), Holme
patent: 4916219 (1990-04-01), Linhandt et al.
Nicholson-Weller et al (1985) Blood 65(5), 1237-1244.
Bausback, J., et al., "F 1 Functionally important domains of C9 as Defined by Monoclonal Antibodies to C9 Inhibiting Hemolysis", Immunobiology, 178:58 (1988).
Hammer, C., et al., "Large Scale Isolation of Functionally Active Components of the Human Complement System", The Journal of Biological Chemistry, 256(8):3995-4006 (1981).
Moongkarndi, A., et al., "Immunological and Functional Properties of Two Monoclonal Antibodies Against Human C5", Immunobiology, 165:323 (1983).
Zalman et al Proc Natl. Acad. Sci. USA vol. 83 6975-79 issued Sep. 1986.
Sims, P. J., "Interaction of human platelets with the complement system", Platelet Immunobiology, Molecular and Clinical Aspects Kunicki and George, editors, p. 354 (J. B. Lippincott Publishers, Philadelphia 1989).
Shin, et al., Prog. Allergy 40, 44 (1988).
Nicholson-Weller, et al., J. Immunol. 129, 184 (1982).
Pandburn, et al. Proc. Natl. Acad, Sci. USA 80, 5430 (1983).
Shin et al., J. Immunol. 136(5), 1777-1782 (1986).
Zalman, et al., Proc. Natl. Acad. Sci. USA 83, 6975 (1986).
Schonermark, et al., J. Immunol. 136, 1772 (1986).
Martin, et al., Proc. Natl. Acad. Sci. USA 85, 213-217 (1988).
Sugita, et al., Proc. Natl. Acad. Sci. USA 85, 213-217 (1988).
Okada, et al., Biochem. Biophys. Res. Comm. 162, 1553 (Aug. 1989).
Davies, et al., J. Exp. Med. 170, 637 (Sep. 1989).
Rollins, et al., Complement and Inflammation 6, 394 (1989).
Wiedmer and Sims, J. Biol. Chem. 260, 8014-8019 (1985).
Wiedmer, et al., J. Biol. Chem. 262, 13674-13681 (1987).
Sims, et al., J. Biol. Chem. 263, 18205-18212 (1988).
Hansch, et al., Blood 72, 1089-1092 (1988).
Blaas, et al., J. Immunol. 140, 3045-3051 (1988).
Shattil, et al., J. Biol. Chem. 260, 11107-11112 (1985).
Zalman, et al., J. Exp. Med. 165, 572-577 (1987).
Hansch, et al., J. Clin. Invest. 80, 7-12 (1987).
Ando, et al., J. Biol. Chem. 263, 11907-11914 (1988).
Ando, et al., Blood 73, 462-467 (1989).
Sims and Wiedmer, Blood 68(2), 556-561 (1986).
Wiedmer, et al., J. Biol. Chem. 261(31), 14587-14592 (1986).
Hattori, et al., J. Biol. Chem. 264(15), 9053-9060 (1989).
Okada, et al., Int. Immunol. 1(2), 205-208 (1989).
Holguin, et al., J. Clin. Invest. 84, 7-17 (Jul. 1989).
Groux, et al., J. Immunol. 142(9), 3013-3020 (May 1989).
Stefanova, et al., Molecular Immunology 26(2), 153-161 (1989).
Sims, et al., J. Biol. Chem. 264(29) 17049-17057 (1989).
Rollins and Sims "The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9", submitted to J. immunol. (1989).
Sims, et al., "Regulatory Control of complement on Blood Platelets: Modulation of Platelet Procoagulant Responses by a membrane inhibitor of the C5b-9" J. Biol. Chem. (1989).
Hamilton, et al., "Complement Proteins C5b-9 Increase Endothelial Prothrombinase Activity" Circulation (1989).
Hamilton, et al., "Complement Proteins C5b-9 Induce vesiculation of the Endothelial Plasma Membrane and Expose Catalytic Surface for Assembly of the Prothrombinase Enzyme Complex", submitted to J. Biol. Chem.
Wiedmer, et al., "The Role of Calcium and Calpain in Complement-Induced Vesiculation of the Platelet Plasma Membrane and in the Exposure of the Platelet Factor Va Receptor".
Pandburn, et al. Proc. Natl. Acad. Sci. USA 80, 5430 (1983).
Shin, et al., J. Immunol. 136(5), 1777-1782 (1986).
Zalman, et al., Proc. Natl. Acad. Sci. USA 83, 6975 (1986).
Schonermark, et al., J. Immunol. 136, 1772 (1986).
Martin, et al., Proc. Natl. Acad. Sci. USA 85, 213-217 (1988).
Sugita, et al., J. Biochem. (Japan), 104, 633-637.
Okada, et al., Biochem. Biophys. Res. Comm. 162, 1553 (Aug. 1989).
Davies, et al., J. Exp. Med. 170, 637 (Sep. 1989).
Rollins, et al., Complement and Inflammation 6, 394 (1989).
Wiedmer and Sims, J. Biol. Chem. 260 8014-8019 (1985).
Wiedmar, et al., J. Biol. Chem. 262, 13674-13681 (1987).
Sims, et al., J. Biol. Chem. 263, 18205-18212 (1988).
Abstracts presented at XIII International Complement Workshop in San Diego, Sep. 10-15 (1989).

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