Inhibition of complement mediated inflammatory response

Details Inhibition of complement mediated inflammatory response Inhibition of complement mediated inflammatory response

1989-06-12

1992-08-04

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 514 12, 530350, 530380, 530830, C07K 1500, A61K 3702, A61K 3764

Patent

active

051359162

ABSTRACT:
A composition and methods for use thereof relating to polypeptides having the ability to act as an inhibitor of complement C5b-9 complex activity. The compositions contain an 18 kDa protein found on the surface of human erythrocytes, a 37 kDa protei

REFERENCES:
patent: 4447415 (1984-05-01), Rock et al.
patent: 4695460 (1989-09-01), Holme
patent: 4916219 (1990-04-01), Linhardt et al.
Nicholson-Weller et al (1985) Blood 65(5), 1237-1244.
Sims, P. J., "Interaction of Human Platelets with the Complement System", Platelet Immunobiology, Molecular and Clinical Aspects Kunicki and George, editors, p. 354 (J. B. Lippincott Publishers, Philadelphia 1989).
Shin, et al., Prog. Allergy 40, 44 (1988).
Nicholson-Weller, et al., J. Immunol. 129, 184 (1982).
Pangburn, et al. Proc. Natl. Acad. Sci. USA 80, 5430 (1983).
Shin, et al., J. Immunol. 136(5), 1777-1782 (1986).
Zalman, et al., Proc. Natl. Acad. Sci. USA 83, 6975 (1986).
Schonermark, et al., J. Immunol. 136, 1772 (1986).
Martin, et al., Proc. Natl. Acad. Sci. USA 85, 213-217 (1988).
Sugita, et al., J. Biochem. (Japan), 104, 633-637.
Okada, et al., Biochem. Biophys. Res. Comm. 162, 1553 (Aug. 1989).
Davies, et al., J. Exp. Med. 170, 637 (Sep. 1989).
Rollins, et al., Complement and Inflammation 6, 394 (1989).
Wiedmer and Sims, J. Biol. Chem. 260, 8014-8019 (1985).
Wiedmer, et al., J. Biol. Chem. 262, 13674-13681 (1987).
Sims, et al., J. Biol. Chem. 263, 18205-18212 (1988).
Hansch, et al., Blood 72, 1089-1092 (1988).
Blaas, et al., J. Immunol. 140, 3045-3051 (1988).
Shattil, et al., J. Biol. Chem. 260, 11107-11112 (1985).
Zalman, et al., J. Exp. Med. 165, 572-577 (1987).
Hansch, et al., J. Clin. Invest. 80, 7-12 (1987).
Ando, et al., J. Biol. Chem. 263, 11907-11914 (1988).
Ando, et al., Blood 73, 462-467 (1989).
Sims and Wiedmer, Blood 68(2), 556-561 (1986).
Wiedmer, et al., J. Biol. Chem. 261(31), 14587-14592 (1986).
Hattori, et al., J. Biol. Chem. 264(15), 9053-9060 (1989).
Schonermark 1988 (remainder of cite unknown).
Okada, et al., Int. Immunol. 1(2), 205-208 (1989).
Holguin, et al., J. Clin. Invest. 84, 7-17 (Jul. 1989).
Abstracts presented at XIII International Complement Workshop in San Diego, Sep. 10-15 (1989).
Groux, et al., J. Immunol. 142(9), 3013-3020 (May 1989).
Stefanova, et al., Molecular Immunology 26(2), 153-161 (1989).
Sims, et al., J. Biol. Chem. 264(29) 17049-17057 (1989).
Rollins and Sims "The Complement-Inhibitory Acitivty of CD59 Resides in Its Capacity to Block Incorporation of C9 into Membrane C5b-9", submitted to J. Immunol. (1989).
Sims, et al. "Regulatory Control of Complement on Blood Platelets: Modulation of Platelet Procogulant Responses by a Membrane Inhibitor of the C5b-9" J. Biol. Chem. (1989).
Hamilton, et al., "Complement Proteins C5b-9 Increase Endothelial Prothrombinase Activity" Circulation (1989).
Hamilton, et al., "Complement Proteins C5b-9 Induce Vesiculation of the Endothelial Plasma Membrane and Expose Catalytic Surface for Assembly of the Prothrombinase Enzyme Complex", submitted to J. Biol. Chem.
Wiedmer, et al., "The Role of Calcium and Calpain in Complement-Induced Vesiculation of the Platelet Plasma Membrane and in the Exposure of the Platelet Factor Va Receptor".

Affiliated with

Also associated with

Rating

Inhibition of complement mediated inflammatory response does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of complement mediated inflammatory response, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of complement mediated inflammatory response will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-778397