Inhibition of cellular uptake of cholesterol

Details Inhibition of cellular uptake of cholesterol Inhibition of cellular uptake of cholesterol

1996-10-29

1999-07-13

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving cholesterol

435 4, 436 71, 552544, C12Q 160

Patent

active

059225548

ABSTRACT:
This invention provides for methods of reducing cholesterol uptake by a cell. The invention is premised in part on the discovery of a new mechanisms by which free cholesterol (FC) is internalized into a cell from low-density lipoproteins. Inhibition of this mechanism reduces the internalization of free cholesterol into cholesterol transport vesicles thereby reducing free cholesterol content of the cell at physiological concentrations of LDL and HDL.

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