Inhibition of cellular proteases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S324000, C530S325000, C530S326000, C514S013800, C435S325000, C424S230100

Reexamination Certificate

active

09748642

ABSTRACT:
The invention provides a method of decreasing viral replication in cells, the method comprising decreasing levels of functional cellular protease in the cells. The invention further provides a method of treating or preventing a viral infection in a subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of functional cellular protease in the cells of the subject.

REFERENCES:
patent: 5478727 (1995-12-01), Roizman et al.
patent: 5607831 (1997-03-01), Henkart et al.
patent: 5684147 (1997-11-01), Agrawal et al.
patent: 5776718 (1998-07-01), Palmer et al.
patent: 5776933 (1998-07-01), Gordon et al.
patent: 5886036 (1999-03-01), Kempf et al.
patent: 5981259 (1999-11-01), Franzusoff
patent: 6015787 (2000-01-01), Potter et al.
patent: 6294518 (2001-09-01), Potter et al.
patent: 6410704 (2002-06-01), Roizman et al.
patent: 0514830 (1992-11-01), None
deJong et al. Summary of the II International Symposium on Cytomegalovirus (mini review). 1998 Antiviral Research, vol. 39: pp. 141-162.
Chen et al. Proceedings of the American Association for Cancer Research Annual Meeting, (Mar. 1999) vol. 40, pp. 447-448. print. Meeting Info.: 90th Annual Meeting of the American Association for Cancer Research. Philadelphia, Pennsylvania, USA. Apr. 10-14, 1999.
Kleina et al., Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus, Dec. 1992, Journal of Virology, vol. 66, pp. 7168-7175.
Kim et al., Coronavirus protein processing and RNA synthesis is inhibited by the cystein proteinase inhibitor E64d, 1995, Virology, vol. 208, pp. 1-8.
Debaisi et al., “Reovirus-Induced Apoptosis Is Preceded by Increased Cellular Calpain Activity and Is Blocked by Calpain Inhibitors”, Journal of Virology 73(1):695-701 (Jan. 1999).
Huang et al., “Ester and Amide Derivatives of E64c as Inhibitors of Platelet Calpains”, J Med Chem 35:2048-2054 (1992).
McGowan et al., “Inhibition of Calpain in Intact Platelets by the Thiol Protease Inhibitor E-64d”, Biochem Biophys Res Com 158(2):432-435 (1989).
Rossi et al., “Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors”, J Biol Chem 273(26):16446-16452 (1998).
Chen et al., J. Virology, 75(8):3613-3625 (2001).
Carafoli et al., Biochemical & Biophysical Research Communications, 247:193-203(1998).
Sicar et al., Antiviral Research 30:147-53(1996).
Everett et al., The EMBO J., 17(24):7161-769(1998).
Bresnahan et al., Virology, 224:150-160(1996).
Kido et al., Biol. Chem., 378:255-63(1997).
Kido et al., Advances in Enzyme Regualtion, 36:325-347(1996).
Kido et al., Biopolymers, 51:79-86(1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibition of cellular proteases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of cellular proteases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of cellular proteases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3754003

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.