Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-01-26
1998-05-26
Rories, Charles C. P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435375, 435377, 435 6, 536 245, A61K 4800, C07H 2100, C12N 510, C12Q 168
Patent
active
057564760
ABSTRACT:
The present invention provides a method of inhibiting restenosis of a blood vessel in a mammal after mechanical treatment of the vessel to reduce a stenosis. The method includes contacting proliferating smooth muscle cells in the vessel with an antisense oligonucleotide directed against a cellular division cycle gene product. This gene product can be one of the following: c-myc, PCNA, and cyclin B.sub.1. The antisense oligonucleotide is used in an amount effective to inhibit translation of the cellular division cycle gene product in the cell.
REFERENCES:
patent: 5023243 (1991-06-01), Tullis
patent: 5593974 (1997-01-01), Rosenberg et al.
Simons et al. "Antisense Approach to Smooth Muscle Proliferation", Supplemental II Circulation 84(4); (1991).
Ch'ng, et al., "Antisense RNA Complementary to 3' Coding and Noncoding Sequences of Creatine Kinase is a Potent Inhibitor of Translation in Vivo", Genetics 86; 10006-10010 (1989).
Dreher, et al., "Expression of Antisense Transcripts Encoding an Extracellular Matrix Protein by Stably Transfected Vascular Smooth Muscle Cells", European Journal of Cell Biology 54; 1-9 (1991).
Harel-Bellan, et al., "Specific Inhibition of c-myc Protein Biosynthesis Using an Antisense Synthetic Deoxy-Oligonucleotide in Human T Lymphocytes", Journal of Immunology 140 (7); 2431-2435 (1988).
Shoemaker, et al., Use of DNA Sequence and Mutant Analyses and Antisense Oligodeoixynucleotides to Examiner the Molecular Basis of Nonmuscle Myosin Light Chain Kinase Autoinhibition, Calmodulin Recognition, and Activity, Journal of Cell Biology 111; 1107-1125 (1990).
Simons, "Naturally Occurring Antisense RNA Control--A Brief Review", Gene 72; 35-44 (1988).
Wickstrom, et al., "Human Promyelocytic Leukemia JL-60 Cell Proliferation and c-MYC Protein Expression are Inhibited by an Antisense Pentadecadeoxynucleotide Targeted Against c-MYC mRNA", Proc. Natl. Acad. Sci. USA, 1988, 85:1028-1032.
Holt, et al., "An Oligomer Complementary to c-MYC mRNA Inhibits Proliferation of HL-60 Promyelocytic Cells and Induces Differentiation", Mol. Cell Biol., 1988, 8:963-973.
Heikkila, et al., "A c-MYC Antisense Oligodeoxynucleotide Inhibits Entry into S Phase but not Progress from G.sub.0 to G.sub.1 ", Nature, 1987, 328:445-449.
Bacon, et al., "Walking Along Human c-MYC mRNA with Antisense Oligodeoxynucleotides: Maximum Efficacy at the 5' Cap Region", Oncogene Res., 1991, 6:13-19.
Lee et al., Circulation Res., vol. 73 No. 5, pp. 797-807 (Nov. 1993).
Biro et al., PNAS USA, vol. 90, pp. 654-658 (Jan. 1993).
Ledley, Human Gene Therapy, vol. 2 (1991) pp. 77-83.
Santoian et al., Circulation, Supp. I, vol. 86 No. 4 (Oct. 1992), No. 3187.
Morishita et al., PNAS USA, vol. 90, pp. 8474-8478, (Sep. 1993).
Ebbecke et al., Eur. Soc. Cardiol. XIIIth Congress (Aug. 1991) No. 177.
Chapman et al., Circulation Res., vol. 71 No. 1, pp. 27-33 (Jul. 1992).
Takeshita, Circulation, Supp. I, vol. 86 No. 4 (Oct. 1992), No. 0903.
King, R.C. and Stanfield, W.D. "A Dictionary of Genetics" 1990, Oxford University Press.
Jaskulski et al. "Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin." Science 240: 1544-1546, 1988.
Ross, R. "The Pathogenesis of Atherosclerosis--An Update" The New England Journal of Medicine 314: 488-500, 1986.
Uhlmann, E. et al. "Antisense Oligonucleotides: A New Therapeutic Principle" Chemical Reviews 90: 543-584, 1990.
Reilly, C. et al. "Heparin Prevents Vascular Smooth Muscle Cell Progression Through the G.sub.1 Phase of the Cell Cycle" J. Biol. Chem. 264: 6990-6995, 1989.
Pines, J. et al. "Isolation of a Human Cyclin cDNA: Evidence for Cyclin mRNA and Protein Regulation in the Cell Cycle and for Interaction with p34.sup.cdc2 " Cell 58:833-846 '89.
Tachibana, K. et al. "The Starfish Egg mRNA Responsible for Meiosis Reinitiation Encodes Cyclin" Devel. Biol. 140 241-252 '90.
Epstein Stephen E.
Speir Edith H.
Unger Ellis F.
Rories Charles C. P.
The United States of America as represented by the Department of
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