Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1997-08-22
2000-10-17
Eyler, Yvonne
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4242831, 436 63, C07K 200, C07K 400, C07K 500, A61K 4500
Patent
active
061334162
ABSTRACT:
The present invention involves the identification of a factor or factors that are anti-proliferative and can be used in the treatment of cancers and other hyperproliferative disease states. The factor or factors are induced from cells follow contact of the cells with viral or plasmid expression vectors. One factor is between about 3 kDa and 300 kDa in size, while another is less than about 3 kDa in size. Both are heat stable and is resistant to both protease and nuclease treatment. Methods for purification and use of the factor also are disclosed.
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Almond Brian D.
Lapadat-Tapolsky Mary
Lee Julia A.
Roth Jack A.
Timmons Therese M.
Eyler Yvonne
The University of Texas System & Board of Regents
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