Inhibition of carbohydrates metabolism by quinone compounds

Details Inhibition of carbohydrates metabolism by quinone compounds Inhibition of carbohydrates metabolism by quinone compounds

1997-04-01

2000-06-13

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514679, 514731, 514732, 568325, 568328, 568731, 568734, A61K 3112, A61K 3105, C07C 49105, C07C 3912

Patent

active

06075057&

ABSTRACT:
Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of .alpha.-glucosidase and .alpha.-mannosidase. Other enzymes assayed were not inhibited by these optically pure compounds. Inhibition of these two enzymes is useful for a variety of assays and probes, and offers particular utility in the treatment of retroviral infection-associated syndromes, such as AIDS.

REFERENCES:
patent: 4939177 (1990-07-01), Muller
patent: 4946869 (1990-08-01), Muller et al.
patent: 5026732 (1991-06-01), Muller
patent: 5204367 (1993-04-01), Wright et al.

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