Inhibition of C. difficile infections by indigestible oligosacch

Details Inhibition of C. difficile infections by indigestible oligosacch Inhibition of C. difficile infections by indigestible oligosacch

1995-04-05

1997-11-18

Seidleck, James J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514183, 514449, 514451, 514453, 514455, 514456, 514461, A01N 4304

Patent

active

056887779

ABSTRACT:
The primary etiology of antibiotic-associated diarrhea (which may lead to pseudomembranous colitis) has been recognized as Clostridium difficile. It is believed that the indigenous microflora of a healthy individual suppresses the normally present C. difficile. However, when the indigenous microflora are disrupted (e.g., during antibiotic treatment) overgrowth of C. difficile may occur causing diarrhea and colitis. Treatment of C. difficile with antibiotics has proven effective, but many times relapse occurs. The present invention involves a non-antibiotic approach to the treatment and/or prevention of C. difficile--associated diseases. A therapeutically effective amount of an indigestible oligosaccharide inhibits the infection of mammals by C. difficile when administered enterally.

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