Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones

Details Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones

1994-05-18

1995-11-14

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30762

Patent

active

054668301

ABSTRACT:
This invention relates to 4-phenoxy (and 4-substituted phenoxy)5-hydroxy-2(5H)-furanones of the formula: ##STR1## where Z is ##STR2## where R is H, halogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, or ##STR3## and X is H, C.sub.1 -C.sub.8 alkyl, --O--C.sub.1 -C.sub.8 alkyl, or halogen;
a process for their preparation, their use in the treatment of osteoporosis, and pharmaceutical compositions thereof.

REFERENCES:
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patent: 4839385 (1989-06-01), Maullem et al.
patent: 4874782 (1989-10-01), Bonjouklian et al.
patent: 4916241 (1990-04-01), Hayward et al.
patent: 5026725 (1991-06-01), Hayward et al.

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