Inhibition of biofilm formation

Details Inhibition of biofilm formation Inhibition of biofilm formation

2005-03-21

2009-10-20

Vogel, Nancy (Department: 1636)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Chemical stimulation of growth or activity by addition of...

C435S252100, C435S252800, C435S253300

Reexamination Certificate

active

07604978

ABSTRACT:
The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.

REFERENCES:
patent: 3996132 (1976-12-01), Mateos et al.
patent: 4606911 (1986-08-01), Hayashi et al.
patent: 4897268 (1990-01-01), Tice et al.
patent: 4929365 (1990-05-01), Clark et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5312813 (1994-05-01), Costerton et al.
patent: 5462644 (1995-10-01), Woodson
patent: 5789239 (1998-08-01), Eyers et al.
patent: 5834437 (1998-11-01), Jew et al.
patent: 5882916 (1999-03-01), Wiersma et al.
patent: 5906825 (1999-05-01), Seabrook et al.
patent: 5985601 (1999-11-01), Nl et al.
patent: 6080323 (2000-06-01), Yu et al.
patent: 6264926 (2001-07-01), Farooqi et al.
patent: 6267897 (2001-07-01), Robertson et al.
patent: 6267979 (2001-07-01), Raad et al.
patent: 6369101 (2002-04-01), Carlson
patent: 6395189 (2002-05-01), Fabri et al.
patent: 6399115 (2002-06-01), Revel
patent: 6410256 (2002-06-01), Ceri et al.
patent: 6423219 (2002-07-01), Chandler
patent: 6455031 (2002-09-01), Davies et al.
patent: 6468549 (2002-10-01), Dupuis et al.
patent: 6498862 (2002-12-01), Pierson et al.
patent: 6555055 (2003-04-01), Cisar et al.
patent: 6585961 (2003-07-01), Stockel
patent: 6596505 (2003-07-01), Ceri et al.
patent: 6669929 (2003-12-01), Boyd et al.
patent: 6762160 (2004-07-01), Barbeau et al.
patent: 6946124 (2005-09-01), Arnaud-Sebillotte et al.
patent: 2002/0037260 (2002-03-01), Budney et al.
patent: 2003/0225126 (2003-12-01), Markham et al.
patent: 2004/0033548 (2004-02-01), Bassler et al.
patent: 2004/0033549 (2004-02-01), Greenberg et al.
patent: 2004/0136924 (2004-07-01), Boyd et al.
patent: 2005/0137259 (2005-06-01), Matsuyama et al.
patent: 2005/0143428 (2005-06-01), Dunkel et al.
patent: 2006/0014285 (2006-01-01), Eldridge et al.
patent: 2006/0014290 (2006-01-01), Eldridge
patent: 2006/0228384 (2006-10-01), Eldridge
patent: 2006/0264411 (2006-11-01), Eldridge
patent: 2007/0014739 (2007-01-01), Eldridge
patent: 2008/0145322 (2008-06-01), Eldridge
patent: WO 98/08091 (1998-02-01), None
patent: WO 98/08091 (1998-02-01), None
patent: WO 2006/010147 (2006-01-01), None
patent: WO 2006/019881 (2006-02-01), None
patent: WO 2006/019926 (2006-02-01), None
patent: WO 2006/031943 (2006-03-01), None
patent: WO 2006/102255 (2006-09-01), None
Delic-Attree et al., Mol. Microbiol., 1997, 24(6), 1275-1284.
Rakonjac et al., Mol. Gen. Genet., 1991, 228, 307-311.
Schuhly et al., Planta Medica, 1999, 65, 740-743.
Chambers 21st Century Dictionary, Chambers Harrap Publishers Limited 2001, Retrieved Jul. 7, 2008, from http://www.credoreference.com/entry/1215201.
International Search Report for PCT/US2006/010088, published by the International Bureau of WIPO on Sep. 28, 2006 under WO 2006/102255 A1.
Anderson et al., Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections,www.sciencemag.org, Jul. 4, 2003, pp. 105-107.
Borum, P. R. and Monty, K. J., Regulatory Mutants and Control of Cysteine Biosynthetic Enzymes inSalmonella typhimurium; Journal of Bacteriology, Jan. 1976, p. 94-101, vol. 125, No. 1, U.S.A.
Ding, H. and Demple, B., Thiol-Mediated Disassembly and Reassembly of [2Fe-2S] Clusters in the Redox-Regulated Transcription Factor SoxR; American Chemical Society, 1998, p. 17280-17286, vol. 37, published on Web Nov. 19, 1998.
Gallardo-Madueno, R., et al., In Vivo Transcription ofnrdABOperon and ofgrxAandfpgGenes I Triggered inEscherichia coliLacking both Thioredoxin and Glutaredoxin 1 or Thioredoxin and Glutathione, Respectively; Journal of Biological Chemistry, Jul. 17, 1998, p. 18382-18388, vol. 273, No. 29, The American Society for Biochemistry and Molecular Biology, Inc., U.S.A.
Hogema, B. M., et al., Inducer exclusion inEscherichia coliby non-PTS substrates: the role of the PEP to pyruvate ratio in determining the phosphorylation state of enzyme IIAGIc, Molecular Microbiology, 1998, p. 487-498, vol. 30(3), Blackwell Science Ltd.
Jackson, D. W. et al., Biofilm Formation and Dispersal under the Influence of the Global Regulator CsrA ofEscherichia coli, Journal of Bacteriology, Jan. 2002, p. 290-301, vol. 184, No. 1.
Kiley, P. J. and Beinert, H., the role of Fe-S proteins in sensing and regulation in bacteria, Current Opinion in Microbiology, 2003, p. 181-185, vol. 6, www.currentopinion.com.
Miranda-Vizuete, A. et al., The Levels of Ribonucleotide Reductase, Thioredoxin, Glutaredoxin 1, and GSH Are Balanced inEscherichia coliK12, The Journal of Biological Chemistry, Aug. 9, 1996, p. 19099-19103, vol. 271, No. 32, The American Society for Biochemistry and Molecular Biology, Inc., U.S.A.
Olofsson, A-C., et al., N-Acetyl-L-Cysteine Affects Growth, Extracellular Polysaccharide Production, and Bacterial biofilm Formation on Solid Surfaces, Applied and Environmental Microbiology, Aug. 2003, p. 4814-4822, vol. 69, No. 8, American Society for Microbiology.
Perez-Giraldo, C. et al., Influence of N-acetylcysteine on the formation of biofilm byStaphylococcus epidermidis, Journal of Antimicrobial Chemotherapy, 1997, p. 643-646, vol. 39, The British Society for Antimicrobial Chemotherapy.
Prieto-Alamo, M-J. et al., Transcriptional Regulation of Glutaredoxin and Thioredoxin Pathways and Related Enzymes in Response to Oxidative Stress, May 5, 2000, p. 13398-13405, vol. 275, No. 18, The American Society for Biochemistry and Molecular Biology, Inc., U.S.A.
Rashid, M. H. et al., Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence ofPseudomonas aeruginosa; Proc. Natl. Acad. Sci. 10.1073/pnas.170283397, Aug. 15, 2000, p. 9636-9641, vol. 97, No. 17.
Singh, P. K. et al., A component of innate immunity prevents bacterial biofilm development; Nature, May 30, 2002, p. 552-555, vol. 417, Nature Publishing Group.
Tran, Q. H., et al. Role of glutathione in the formation of the active form of the oxygen sensor FNR ([4Fe-4S]-FNR) and in control of FNR function, Eur. J. Biochem., 2000, p. 4817-4824, vol. 267.
Vergauwen, B., et al., Exogenous Glutathione Completes the Defense against Oxidative Stress inHaemophilus influenzae, Journal of Bacteriology, Mar. 2003, p. 1572-1581, vol. 185, No. 5, American Society for Microbiology.
International Search Report for PCT/US2005/24946 (WO 2006/010147), Publication Date Jan. 26, 2006, Eldridge, Gary R.
International Search Report for PCT/US2005/25016 (WO/2006/019926 A2), Publication Date Feb. 23, 2006, Eldridge, Gary R.
International Search Report for PCT/US2005/032874 (WO 2006/03943), Publication Date filed Mar. 23, 2006, Eldridge, Gary R.
International Search Report for PCT/US2005/24945 (No WO publication), Publication Date Apr. 18, 2006, Eldridge, Gary R.
Adler and Epstein, Phosphotransferase-System Enzymes as Chemoreceptors for Certain Sugars inEscherichia coliChemotaxis, Proc. Nat. Acad. Sci. USA, Jul. 1974, 71(7): 2895-2899.
Akamatsu, H. et al., the inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne, Archives of Dermatological Research, 1990, 282: 449-454.
Ando, E. et al., Biofilm Formation Among Methicillin-ResistantStaphylococcus aureusIsolates from Patients with Urinary Tract Infection, Acta Med. Okayama, 2004, 58(4): 207-214.
Arevalo-Ferro, C. et al., Biofilm formation ofPseudomonas putidaIsoF: the role of quorum sensing as assessed by proteomics, Systematic and Aplplied Microbiology, 2005, 28: 87-114.
Bannon, C. D. et al, Chlorination of Olean-12-Enes, Database Accession No. 1976:44437 Abstract & Australian Journal of Chemistry, 1976, pp. 2649-2654, vol. 28, No. 12.
Begum, S. et al, Chemical Constituents From the Leaves of Psidium Guajava, Database Accession No. 2004:177767 Abstract & Natural Product Research, 2004, pp. 135-140, vol. 18, No. 2.
B

Affiliated with

Also associated with

Rating

Inhibition of biofilm formation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of biofilm formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of biofilm formation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4066682