Inhibition of BEHAB cleavage and primary central nervous...

Details Inhibition of BEHAB cleavage and primary central nervous... Inhibition of BEHAB cleavage and primary central nervous...

2005-04-26

2005-04-26

LeGuyader, John L. (Department: 1635)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S006120, C435S091100, C435S375000, C536S023100, C536S024100, C536S024300, C536S024330, C536S024500

Reexamination Certificate

active

06884619

ABSTRACT:
The present invention relates to primary CNS tumors and provides useful compositions and methods for reducing tumor volume and increasing the length of survival in mammals with primary CNS tumors, thereby providing a treatment for primary CNS tumors. The invention also relates to methods of identifying compounds for reducing tumor volume and increasing animal survival, which therefore relate to treating primary CNS tumors.

REFERENCES:
patent: 4160452 (1979-07-01), Theeuwes
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4728512 (1988-03-01), Mehta et al.
patent: 4728513 (1988-03-01), Ventouras
patent: 4786600 (1988-11-01), Kramer et al.
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4876187 (1989-10-01), Duck et al.
patent: 5011769 (1991-04-01), Duck et al.
patent: 5023243 (1991-06-01), Tullis
patent: 5084287 (1992-01-01), Ghebre-Sellassie et al.
patent: 5168053 (1992-12-01), Altman et al.
patent: 5190931 (1993-03-01), Inouye
patent: 5285186 (1994-02-01), Chen
patent: 5635370 (1997-06-01), Hockfield et al.
patent: 6180370 (2001-01-01), Queen et al.
patent: WO 8702671 (1987-05-01), None
Yamada et al. cDNA cloning and the identificationof an aggrecanase-like cleavage site in rat brevican. Biochemical and Biophysical Research Communications, 1995 vol. 216:957-963.*
Asperg et al. The c-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Proc. Natl. Acad. Sci., 1997 vol. 94:10116-10121.*
Zhang et al. The G3 domain of versican inhibits mesenchymal chondrogenesis via the epidermal growtn factor-like motifs. Journal of Biological Chemistry, 1998 vol. 273:33054-33063.*
Yamada, H. et al., “cDNA Cloning And The Identification Of An Aggrecanase-Like Cleavage Site In Rat Brevican,” Biochemical And Biophysical Research Communications, vol. 216, No. 3, pp. 957-963 (Nov. 22, 1995).
Ausubel et al., 1997, Current Protocols in Molecular Biology, John Wiley & Sons, New York.
Barbas, Synthetic Human Antibodies, Nature Medicine, vol. 1, No. 8, pps. 837-839, Aug., 1995.
Bartel et al., The Yeast Two-Hybrid System, Oxford University Press, Cary, NC.
Beerli et al., Inhibition of Signaling From Type 1 Receptor Tyrosine Kinases via Intracellular Expression of Single-Chain Antibodies, Breast Cancer Research and Treatment, 38: 11-17, 1996 Kluwer Academic Publishers, Netherlands.
Bej et al., Polymerase Chain Reaction-Gene Probe Detection of Microorganisms by Using Filter-Concentrated Samples, Applied and Environmental Microbiology, vol. 57, No. 12, pps. 3529-3534, Dec. 1991.
Beychok, Cells of Immunoglobulin Synthesis, Academic Press, New York, 1979.
Bird et al., Single-Chain Antigen-Binding Proteins, Science vol. 242, pp. 423-426, Oct., 1988.
Blais, Burton W., Transcriptional Enhancement of theListeria MonocytogenesPCR and Simple Immunoenzymatic Assay of the Product Using Anti-RNA:DNA Antibodies, Applied and Environmental Microbiology, vol. 60, No. 1, pps. 348-352, Jan., 1994.
Bodansky et al., The Practice of Peptide Synthesis, 1984, Springer-Verlag, New York.
Burton et al., Human Antibodies from Combinatorial Libraries, Advances in Immunology, vol. 57 pp. 191-280, 1994.
Cech, Thomas R., Ribozymes and Their Medical Implications, J. Amer. Med. Assn. vol. 260, No. 20, pps. 3030-3034, Nov., 25, 1988.
Cech et al., RNA Catalysis by a Group 1 Ribozyme, The Journal of Biol. Chem. vol. 267No. 25, pps. 17479-17482, The American Society for Biochemistry and Molecular Biology, Inc., Printed in U.S.A.
Cohen, 1989, In: Oligodeoxyribonucleotides, Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, FL.
DeClerk et al., Inhibition of Tumor Invasion of Smooth Muscle Cell Layers by Recombinant Human Metalloproteinase Inhibitor, Cancer Research 51: 2151-2157, Apr. 15, 1991.
De Kruif et al., Selection and Application of Human Single Chain Fv Antibody Fragments From a Semi-Synthetic Phage Antibody Display Library With Designed CDR3 Regions, J. Mol. Biol. 248: 97-105, 1995, Academic Press Limited.
Delpech et al., The Origin of Hyaluronectin in Human Tumors, International Journal of Cancer vol. 72, 942-948, 1997 Wiley-Liss, Inc.
Deryugina et al., Matrix Metalloproteinase-2 Activation Modulates Glioma Cell Migration, Journal of Cell Science 110: 2473-2482, Printed in Great Britain © The Company of Biologists Limited, 1997.
Duplaa et al., Quantitative Analysis of Polymerase Chain Reaction Products Using Biotinylated dUTP Incorporation, Anal. Biochem. 212: 229-236, © 1993 by Academic Press, Inc.
Forsyth et al., Gelatinase-A (MMP-2), Gelatinase-B (MMP-9) and Membrane Type Matrix Metalloproteinase-1 (MT1-MMP) are Involved in Different Aspects of the Pathophysiuology of Malignant Gliomas, British Journal of Cancer 79: 1828-1835, © 1999 Cancer Research Campaign.
Fosang et al., Generation and Novel Distribution of Matrix Metalloproteinase-derived Aggrecan Fragments in Porcine Cartilage Explants, J. Biol. Chem., 275: 33027-33037, 2000 © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Furcht et al., Tumor Cell Invasion, Matrix Metalloproteinases, and the Dogma, Laboratory Investigation 70: 781-783, © 1994 The United States and Canadian Academy of Pathology, Inc.
Gary et al., BEHAB/Brevican: A Brain-Specific Lectican Implicated in Gliomas and Glial Cell Motility, 2000, Gene 2356: 139-147.
Genaro et al., 1985, Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, PA.
Gillam et al., Site-Specific Mutagenesis Using Synthetic Oligodeoxyribonucleotide Primers: I. Optimum Conditions and Minimum Oligodeoxyribonucleotide Length, Gene, vol. 8 pp. 81-97, 1979, Elsevier/North-Holland Biomedical Press.
Goldbrunner et al., Cell-Extracellular Matrix Interaction in Glioma Invasion, Acta Neurochirurgica 141:295-305, © Springer-Verlag 1999, printed in Austria.
Gu et al., Construction and Expression of Mouse-Human Chimeric Antibody SZ-51 Specific for Activated Platelet P-Selectin, 1997, Thrombosis and Hematocyst 77: 755-759.
Hall et al., Hyaluronan: RHAMM Mediated Cell Locomotion and signaling in Tumorigenesis, Journal of Neuro-Oncology 26:221-229, © 1995 Kluwer Academic Publishers, printed in the Netherlands.
Hall et al., Overexpression of the Hyaluronan Receptor RHAMM is Transforming and is Also Required for H-ras Transformation, Cell 82: 19-28, © 1995 by Cell Press.
Hamasuna et al., Regulation of Matrix Metalloproteinase-2 (MMP-2) by Hepatocyte Growth Factor/Scatter Factor (HGF/SF) in Human Glioma Cells: HGF/SF Enhances MMP-2 Expression and Activation Accomanying Up-Regulation of Membrane Type-1 MMP, International Journal of Cancer 82: 274-281 © 1999 Wiley-Liss, Inc.
Hampel et al., RNA Catalytic Properties of the Minimum (-)s TRSV Sequence, Biochemistry 28: 4929-4933, © 1989 American Chemical Society.
Harlow et al., 1988, Using Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, NY.
Heath et al., Clinical Potential of Matrix Metalloprotease Inhibitors in Cancer Therapy, Drugs 59: 1043-1055, © Adis International Limited, May, 2000.
Higuchi et al., Kinetic PCR Analysis: Real-Time Monitoring of DNA Amplification Reactions, Bio/Technology 11: 1026-1030, Sep., 1993.
Hockfield, Proteoglycans in Neural Development, Semin. Dev. Biol. 1:55-63, © 1990 by W.B. Saunders Company.
Huston et al., Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv Analogue Produced inEscherichia coli, Proc. Natl. Acad. Sci. USA 85: 5879-5883, Aug., 1988.
Iida et al., Rapid and Sensitive Method for Detection of Salmonella Strains Using a Combination of Polymerase Chain Reaction and Reverse Dot-blot hybridization, FEMS Microbiol. Lett. 114: 167-172, © 1993 Federation of European Microbiological Societies.
Jaworski et al., BEHAB, a New Member of the Proteoglycan Tandem Repeat Family of Hyaluronan-binding Proteins That is Restricted

Affiliated with

Also associated with

Rating

Inhibition of BEHAB cleavage and primary central nervous... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of BEHAB cleavage and primary central nervous..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of BEHAB cleavage and primary central nervous... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3386679