Inhibition of bacterial binding by high-mannose oligosaccharides

Details Inhibition of bacterial binding by high-mannose oligosaccharides Inhibition of bacterial binding by high-mannose oligosaccharides

1997-09-18

1999-08-17

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 72, 435 32, G01N 33554, G01N 3353, C12Q 118

Patent

active

059392797

ABSTRACT:
The present invention describes a method for the treatment of gram-negative bacterial infections using high-mannose containing oligosaccharides. Specifically the use of Man.sub.9 (GlcNAc).sub.2 -hydrophobic glycopeptides (i.e. tyrosinamide) to block adhesion of the bacteria pili to the oligosaccharide of the host cells plasma membrane in infections of Enterobacter cloacae and other Enterobacter and gram-negative species.

REFERENCES:
Wold et al., "Secretory Immunoglobulin A carries oligosaccharide receptors for E. coli typy 1 fimbrial lectin", Infection and Immunity, Sep. 1990, vol. 58, No. 9 pp. 3073-3077.
Firon et al., "Interaction of manose-containing oligosaccharides with the fimbrial lectin of E. coli", Biochem Biophys. Res. Commun., 1982, 105, pp. 1426-1432.
Jones et al. "FimH adhesin of type I pili is assembled into a fibrillar tip structure in the Enterobacteriaceae", Proc. Natl. Acad. Sci. USA, Mar. 1995, vol. 92, pp. 2081-2085.
Elbein et al., "Glycosidase inhibitors: inhibitors of N-linked oligosaccharide processing", FASEB, Dec. 1991, vol. 5, pp. 3055-3063.
Eden et al., "Inhibition of Bacterial Attachment", Current Topics in Microbiology, 1990, vol. 151, pp. 167-183.

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