Inhibition of B-cell maturation and antibody production

Details Inhibition of B-cell maturation and antibody production Inhibition of B-cell maturation and antibody production

2006-01-11

2009-02-17

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

Reexamination Certificate

active

07491506

ABSTRACT:
The present invention provides methods and compositions for the inhibition of B-cell maturation and antibody production without interfering with innate or T-cell mediated immunity.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5225347 (1993-07-01), Goldberg
patent: 5246921 (1993-09-01), Reddy et al.
patent: 5500357 (1996-03-01), Taira et al.
patent: 5527895 (1996-06-01), Hampel et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 6252043 (2001-06-01), Hession et al.
patent: 140 308 (1985-05-01), None
Gibson et al., “A Novel Method for Real Time Quantitative RT-PCR,” Genome Res. 6:995 (1996).
Maniatis et al. “Regulation of Inducible and Tissue-Specific Gene Expression,” Science 236:1237 (1987).
Sambrook et al.,Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, New York, pp. 16.7-16.8 (1989).
Anderson and Young, Quantitative Filter Hybridization,in Nucleic Acid Hybridization(1985).
Sambrook et al.,Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, NY, pp. 9.31-9.58 (1989).
Sambrook et al.,Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, NY, pp. 7.39-7.52 (1989).
Crowther, “Enzyme-Linked Immunosorbent Assay (ELISA),” inMolecular Biomethods Handbook, Rapley et al. [eds.], pp. 595-617, Humana Press, Inc., Totowa, NJ (1998).
Harlow and Lane (eds.),Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press (1988).
Ausubel et al. (eds.),Current Protocols in Molecular Biology, Ch. 11, John Wiley & Sons, Inc., New York (1994).
Ghosh et al., “NF-κB and Rel Proteins: Evolunionarily Conserved Mediators of Immune Responses,” Ann. Rev. Immunol. 16:255-260 (1998).
Rothwarf and Karin, “The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus,” Science Signal Transduction Knowledge Environment (STKE) (1999).
Karin et al., “Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity,” Ann. Rev. Immunol. 18:621 (2000).
Palombella et al., “The Ubiquitin-Proteasome Pathway is Required for Processing the NF-κB1 Precursur Protein and the Activation of NF-κB,” Cell 78:773, 1994.
Mercurio et al., “p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction,” Genes Develop. 7:705 (1993).
Lin et al., “Cotranslational Biogenesis of NF-κB p50 by the 26S Proteasome,” Cell 92:819 (1998).
Dumitru et al., “TNF-α Induction by LPS Is Regulated Posttranscriptionally via a TP12/ERKDependent Pathway,” Cell 103:1071 (2000).
Liou et al., “Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation,” Mol. Cell. Biol. 14:5349 (1994).
Yamada et al., “Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase,” J. Immunol. 165:804 (2000).
Shinkura et al., “Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase,”Nat. Genet. 22:74 (1999).
Yin et al., “Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice,” Science 291:2162 (2001).
Xiao et al., “NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100,” Mol. Cell. 7:401 (2001).
Malinin et al., “MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1,” Nature 385:540-4 (1997).
Zandi et al.,“The IκB kinase complex (IKK) contains two kinase subunits, IKKα, and IKKβ, necessary for IκB phosphorylation and NF-κB activation,”Cell91:243-252 (1997).
Zandi et al., “Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate,” 281:1360 (1998).
Mercurio et al., “IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NK-κB Activation,” Science 278:860 (1997).
Woronicz et al., “IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK,” Science 278:866 (1997).
Li et al., “Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene,” Science 284:321 (1999).
Li et al., “The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis,” J. Exp. Med. 189:1839 (1999).
Tanaka et al., “Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice,” Immunity 10:421-429 (1999).
Chu et al., “JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection ,” Immunity 11:721 (1999).
Senftleben et al., “IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis,” Immunity 14:217 (2001).
Hu et al., “Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase,” Science 284:316-320 (1999).
Takeda et al., “Limb and skin abnormalities in mice lacking IKKα,” Science 284:313-316 (1999).
Hu et al., “IKKα controls formation of the epidermis independently of NF-κB,” Nature 410:710 (2001).
Lu et al., “The antibacterial arm of theDrosophilainnate immune response requires an IκB kinase,” Genes Develop. 15:104 (2001).
Kaisho et al., “IκB Kinase α Is Essential for Mature B Cell Development and Function,” J. Exp. Med. 193:417 (2001).
Caamano et al., “Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell-mediated Immune Responses,” J. Exp. Med. 187:185 (1998).
Franzoso et al., Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture, J. Exp. Med. 187:147 (1998).
Fütterer et al., “The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues,” Immun. 9:59 (1998).
Yan et al., “Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity,” Nat. Immun. 1:37 (2000).
Ling et al., “NF-B-inducing kinase activates IKK- by phosphorylation of Ser-176,” Proc Natl Acad Sci USA 95: 3792-3797 (1998).
Huse et al., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda,” Science 246:1275-1281 (1989).
Winter and Harris, “Humanized antibodies,” Immunol. Today 14:243-246 (1993).
Ward et al., “Binding activities of a repertoire of single immunoglobulin variable domains secreted fromEscherichia coli,” Nature 341:544-546 (1989).
Markus-Sekura, “Techniques for Using Anitsense Oligodeoxyribonucleotides to Study Gene Expression,” Anal. Biochem. 172:289-295 (1988).
Hambor et al., “Functional Consequences of Anti-Sense RNA-Mediated Inhibition of CD8 Surface Expression in a Human T Cell Clone,” J. Exp. Med. 168:1237-1245 (1988).
Genbank Sequence Accession No. AF080157 (1999).
Kruger et al., “Self-Splicing RNA: Autoexcision and Autocyclization of the Ribosomal RNA Intervening Sequence of Tetrahymena,” Cell 31: 147-157 (1982).
Guerrier-Takada et al.,“The RNA Moiety of Ribonuclease P is the Catalytic Subunit of the Enzyme,” Cell 35: 849-857 (1983).
Wu et al., “Reversible Cleavage and Ligation of Hepatitis Delta Virus RNA,” Science 243:652-655 (1989).
Hofacker et al., “Fast Folding and Comparison of RNA Secondary Structures,” Monatshefte F. Chemie 125:167-188 (1994).
Mc

Affiliated with

Also associated with

Rating

Inhibition of B-cell maturation and antibody production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of B-cell maturation and antibody production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of B-cell maturation and antibody production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4109439