Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-11-03
2011-12-13
Angell, Jon E (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
Reexamination Certificate
active
08076308
ABSTRACT:
There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or radiation therapy, by inhibiting the expression of one or more genes involved in the cellular autophagy response. The compositions include compositions comprising an siRNA directed against an Atg gene and may be used to inhibit expression of an Atg gene in a cell currently undergoing cancer therapy, or to treat, inhibit or prevent cancer in a subject in combination with a cancer therapy.
REFERENCES:
patent: 6982252 (2006-01-01), Paglin et al.
patent: 2002/0156025 (2002-10-01), Paglin et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
Ui-Tei et al. (Nucleic Acids Research, 2004, 34(3):936-948).
Santiago, F.S. et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nature Medicine. 1999, vol. 5, pp. 1264-1269.
Dykxhoorn, D. M., et al. The silent treatment: siRNAs as small molecule drugs. Gene Therapy. 2006, vol. 13, pp. 541-552.
Morrissey, D. V., et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nature Biotechnology. 2005, vol. 23, No. 8, pp. 1002-1007.
Santel, A., et al. RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy. Gene Therapy. 2006, vol. 13, No. 18, pp. 1360-1370.
Hubbard, T. J. P., et al. Ensembl 2007. Nucleic Acid Research. 2007, vol. 35, database issue: D610-D617.
Klionsky, D. J., et al. A unified nomenclature for yeast autophagy-related genes. Developmental Cell. 2003, vol. 5, No. 4, pp. 539-545.
Mizushima, N., et al. Autophagosome Formation in Mammalian Cells. Cell Structure and Function. 2002, v. 27, No. 6, pp. 421-429.
National Cancer Institute of Canada. Canadian Cancer Statistics 2004, Toronto, Canada, 2004.
Levine, B., Klionsky, D. J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Developmental Cell. 2004, vol. 6, No. 4, pp. 463-477.
Shintani, T., Klionsky, D. J. Autophagy in health and disease: a double-edged sword. Science. 2004, vol. 306, pp. 990-995.
Klionsky, D. J., Emr, S. D. Autophagy as a regulated pathway of cellular degradation. Science. 2000, vol. 290, pp. 1717-1721.
Sledz, C. A., et al. Activation of the interferon system by short-interfering RNAs. Nature Cell Biology. 2003, vol. 5, No. 9, pp. 834-839.
Yue Z., et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 2003, vol. 100, No. 25, pp. 15077-15082.
Bursch, W., et al. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis. 1996, vol. 17, pp. 1595-1607.
Bilir, A., et al. Autophagy and nuclear changes in FM3A breast tumor cells after epirubicin, medroxyprogesterone and tamoxifen treatment in vitro. Pathobiology. 2001, vol. 69, No. 3, pp. 120-126.
Paglin, S., et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Research. 2001, vol. 61, pp. 439-444.
McManus, M. T., et al. Gene silencing in mammals by small interfering RNAs. Nature Reviews Genetics. 2002, vol. 3, No. 10, pp. 737-747.
Bursch, W., et al. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. Journal of Cell Science. 2000, vol. 113, Pt. 7, pp. 1189-1198.
Boya, P., et al. Inhibition of macroautophagy triggers apoptosis. Molecular and Cellular Biology. 2005, vol. 25, pp. 1025-1040.
Mizushima, N. Methods for monitoring autophagy. International Journal of Biochemistry and Cell Biology. 2004, vol. 36, No. 12, pp. 2491-2502.
Dragowska, W. H., et al. HER-2
eu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization. Molecular Cancer Research. 2004, vol. 2, No. 11, pp. 606-619.
Waterhouse, D. N., et al. Trastuzumab and Liposomal Doxorubicin in the Treatment of MCF-7 Xenograft Tumor-Bearing Mice: Combination does not affect drug serum levels. Pharmaceutical Research. 2005, vol. 22, No. 6, pp. 915-922.
Brummelkamp, T. R., et al. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002, vol. 296, No. 5567, pp. 550-553.
Minakuchi, Y., et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Research. 2004, vol. 32, No. 13, p. e109.
Lee, J. H., et al. Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein. Cancer Research. 2005, vol. 65, No. 19, pp. 8993-9003.
Yu, L., et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004, vol. 304, No. 5676, pp. 1500-1502.
Bonetta, L. RNAi: Silencing never sounded better. Nature Methods. 2004, vol. 1, No. 1, pp. 79-86.
Pushparaj, P. N., Melendez, A. J. Short interfering RNA (siRNA) as a novel therapeutic. Clinical and Experimental Pharmacology and Physiology. 2006, vol. 33, No. 5-6, pp. 504-510.
Pattingre, S., et al. Bel-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005, vol. 122, No. 6, pp. 927-939.
Opipari, A. W., et al. Resveratrol induced autophagocytosis in ovarian cancer cells. Cancer Research. 2004, vol. 64, No. 2, pp. 696-703.
Ito, H., et al. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. International Journal of Oncology. 2005, vol. 26, No. 5, pp. 1401-1410.
Chou, T. C., Talalay, P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Advances in Enzyme Regulation. 1984, vol. 22, pp. 27-55.
Kondo, Y., et al. The role of autophagy in cancer development and response to therapy. Nature Reviews Cancer. 2005, vol. 5, pp. 726-734.
Wu, L., et al. Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts. Cancer Research. 2005, vol. 65, No. 7, pp. 2825-2831.
Qadir, A. M., et al. Sensitizing breast cancer cells to chemotherapy by inhibiting autophagy. Poster presentation Nov. 4, 2005.
Yoshimori, T., et al. Autophagy: a regulated bulk degradation process inside cells. Biochemical and Biophysical Research Communications. 2004, vol. 313, No. 2, pp. 453-458.
Niemann, A., et al. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe. Journal of Histochemistry and Cytochemistry. 2000, vol. 48, No. 2, pp. 251-258.
Tsujimoto, Y., Shimizu, S. Another way to die: autophagic programmed cell death. Cell Death and Differentiation. 2005, vol. 12, pp. 1528-1534.
Abedin, M. J., et al. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death and Differentiation. 2006, pp. 1-11.
Hippert, M. M., et al. Autophagy in cancer: good, bad, or both? Cancer Research. 2006, vol. 66, No. 19, 9349-9351.
Boya, P., et al. Inhibition of macroautophagy triggers apoptosis. Molecular and Cellular Biology. 2005, vol. 25, No. 3, pp. 1025-1040.
Takacs-Vellai et al., “Inactivation of the Autophagy Gene bec-1 Triggers Apoptotic Cell Death inC. elegens” Current Biology, Current Science, GB LNKD; vol. 15, No. 16 (2005) pp. 1513-1517.
Gorski Sharon Margaret
Qadir Mohammad Abdul
Angell Jon E
Bozicevic Field & Francis LLP
British Columbia Cancer Agency
Field Bret E.
LandOfFree
Inhibition of autophagy genes in cancer chemotherapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of autophagy genes in cancer chemotherapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of autophagy genes in cancer chemotherapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4314896