Inhibition of attachment of H.influenzae to human cells

Details Inhibition of attachment of H.influenzae to human cells Inhibition of attachment of H.influenzae to human cells

1996-10-23

1998-01-13

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 12, 530324, 530350, 530360, 530361, 530832, 424535, A61K 3800, C07K 1700

Patent

active

057079684

ABSTRACT:
The attachment of H. influenzae to human cells, such as oropharyngeal cells, may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of otitis media in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.

REFERENCES:
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Anianson et al., "Anti-adhesive Activity of Human Casein Against Streptococcus pneumoniae and Haemophilus influenzae", Microbial Pathogenesis, 8:315-323 (1990).
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