Inhibition of apoptosis in keratinocytes by a ligand of p75...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S198100, C530S300000

Reexamination Certificate

active

09018194

ABSTRACT:
Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.

REFERENCES:
patent: 4621023 (1986-11-01), Redziniak et al.
patent: 5077211 (1991-12-01), Yarosh
patent: 6103689 (2000-08-01), Gilchrest et al.
patent: 6242416 (2001-06-01), Gilchrest et al.
patent: 0 584 452 (1994-03-01), None
patent: 63183518 (1988-07-01), None
patent: 63301810 (1988-12-01), None
patent: 11 029441 (1999-02-01), None
patent: 92/18149 (1992-10-01), None
patent: 95-21193 (1995-08-01), None
patent: WO 96/06633 (1996-03-01), None
patent: 96/12955 (1996-05-01), None
patent: WO 97/37228 (1997-10-01), None
Yaar, M, et al, J. Dermatol. 108:568a, whole abstract.
Ben-Ari, B. 2000, Bioscience, 50(4): 303-308.
Christensen, D. 2001, Science News, 160: 254-255.
Zigmond, M.J. (editor). 1999, Fundamental Neuroscience, Academic Press, pp. 616-620.
Zigmond, M.J. (editor). 1999, Fundamental Neuroscience, Academic Press, pp. 616-620, esp Figure 21.6.
Christensen, Science News, 160, 254, 2001.
Detmar, et al,1993, J. Invest. Dermatol., Supplement 101(1): 130s-134s.
Moll, I., 1995, J. Invest. Dermatol., 105(1): 14-21.
Straile, et al, 1961, J. Exp. Zool. 148: 205-221.
Paus, et al, 1997, J. Invest. Dermatol. 2(1): 61-68.
Detmar, et al, 1993, J. Invest. Dermatol., 101: 130S-134S.
Moll, I., 1996, Arch Dermatol Res, 288: 604-610.
R. Paus, et al., “Neural Mechanisms of Hair Growth Control,” JID Symposium, 2(1):61-67 (Aug. 1997).
M. Yaarm et al., “Human Melanocytes as a Mold System for Studies of Alzheimer Disease,”Arch Dematol., 133:1287-1291 (Oct. 1977).
Zhai, S., et al., “Activation of p75 nerve growth factor receptor is blocked by cyclic peptides containing a lysine-glycine-alanine (KGA) motif,”Jour. of Investigative Dermatology, 110 (4) :481 (1998).
Zhai, S. et al., “A Role for P75 Nerve Growth Factor Receptor in Programmed Melanocyte Cell Death After Injury and With Aging,”Journal of Investigative Dermatology 102(4):545, SID Abstract #131 (1994).
Yaar, M. et al., “Cloning and Expression of a Novel Nerve Growth Factor Related Molecule in Human Skin,”Journal of Investigate Dermatology 100(4):548, Abstract #100 (1993).
Yaar, M. et al., “Melanocyte Function in Human Skin is Modulated by Neurotrophic Factors through TRK Receptors,”Journal of Investigate Dermatology 100(4):511, Abstract #(1993).
Zhai, Sen et al., “Nerve Growth Factor (NGF) Enhances Survival of Human Melancytes,”Journal of Investigative Dermatology 101:434, Abstract #279 (1993).
Yaar, M. et al. “Involvement of TRK Proto-Oncogene in Physiological Stimuli of Human Melanocytes,”Clinical Research 40(2):531A, SID Abstracts, (1992).
Price, Vera H., “Alopecia Areata: Clinical Aspects,”Journal of Investigative Dermatology 96(5), Supplement:68S (1991).
Yaar, Mina and Gilchrest, Barabara A, “Human Melanocyte Growth and Differentiation: A Decade of New Data,”Journal of Investigative Dermatology 97(4) :611-617 (1991).
Goldsmith, Lowell A., “Summary of Alopecia Areata Research Workshop and Future Research Directions,”Journal of Investigative Dermatology 96(5), Supplement:98S-100S (1991).
Friedmann, Peter S., “Clinical and Immunologic Associations of Alopecia Areata,”Seminars in Dermatology 4(1) :9-15 (1985).
Stenn, K.S. et al., “Expression of the bcl-2 Protooncogene in the Cycling Adult Mouse Hair Follicle,”Journal of Investigative Dermatology 103(1) :107-111 (1994).
Rabizadeh, Shahrooz et al., “Induction of Apoptosis by the Low-Affinity NGF Receptor,”Science 261:345-348 (1993).
Garcia, Irene et al., “Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene,”Science 258:302-304 (1992).
Allsopp, Timothy E. et al., “The Proto-Oncogene bcl-2 Can Selectivity Rescue Neurotrophic Factor-Dependent Neurons from Apoptosis,”Cell73:295-307 (1993).
Veis, Deborah J. et al., “Bcl-2-Deficient Mice Demonstrate Fulminant Lymphoid Apoptosis, Polycystic Kidneys, and Hypopigmented Hair,”Cell 75:229-240 (1993).
Di Marco, Eddi et al., “Growth-regulated Synthesis and Secretion of Biologically Active Nerve Growth Factor by Human Keratinocytes,”Journal of Biological Chemistry 266(32) :21718-21722 (1991).
Yaar, Mina et al., “Evidence for Nerve Growth Factor-mediated Paracrine Effects in Human Epidermis,”Journal of Cell Biology 115(3) :821-828 (1991).
Barinaga, Marcia “Death Gives Birth to the Nervous System. But How?”Science 259:762-763 (1993).
Hockenbery, David M. et al., “Bcl-2 Functions in an Antioxidant Pathway to Prevent Apoptosis,”Cell 75:241-251 (1993).
Di Marco, Eddi et al., “Molecular Cloning oftrkE, a Noveltrk-related Putative Tyrosine Kinase Receptor Isolated from Normal Human Keratinocytes and Widely Expressed by Normal Human Tissues,”Journal of Biological Chemistry 268(32) :24290-24295 (1993).
Peacocke, Monica et al., “Induction of nerve growth factor receptors on cultured human melanocytes,”Proc. Natl. Acad. Sci. USA 85:5282-5286 (1988).
Barinaga, Marcia, “Cell Suicide: By ICE, Not Fire,”Science 263:754-756 (1994).
Paus, R. et al., “Telogen skin contains an inhibitor of hair growth,”British Journal of Dermatology 122:777-784 (1990).
Ross, Alonzo H. et al., “Characterization of nerve growth factor receptor in neural crest tumors using monoclonal anitbodies,”Proc. Natl. Acad. Sci. USA 81:6681-6685 (1984).
Halaban, R. et al., “Basic Fibroblast Growth Factor from Human Keratinocytes Is a Natural Mitogen for Melanocytes,”Journal of Cell Biology 107:1611-1619 (1988).
Halaban, Ruth et al., “bFGF is the Putative Natural Growth Facto For Human Melanocytes,”In Vitro Celluar&Developmental Biology 23(1) :47-52 (1987).
Ullrich, Axel et al., “Human β-nerve growth factor gene sequence highly homologous to that of mouse,”Nature 303:821-825 (1983).
Morgentstern, Jay P. and Land, Hartmut, “Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line,”Nucleic Acids Research 18(12) :3587-3596 (1990).
Johnson, Dan et al., “Expression and Structure of the Human NGF Receptor,”Cell 47:545-554 (1986).
Heuer, Josef G. et al., “Structure and Developmental Expression of the Chicken NGF Receptor,”Developmental Biology 137:287-304 (1990).
Large, Thomas H. et al., “Structure and Developmental Expression of the Nerve Growth Factor Receptor in the Chicken Central Nervous System,”Neuron 2:1123-1134 (1989).
Radeke, Monte J. et al., “Gene transfer and molecular cloning of the rat nerve growth factor receptor,”Nature 325:593-597 (1987).
Mitchell, Andrew J. and Krull, Edward A., “Alopecia areata: Pathogenesis and treatment,”Journal of the American Academy of Dermatology 11(5)I:763-775 (1984).
Klein, Rüdiger et al., “ThetrkProto-Oncogene Encodes a Receptor for Nerve Growth Factor,”Cell 65:189-197 (1991).
Maisonpierre, Peter C. et al., “Neurotrophin-3: A Neurotrophic Factor Related to NGF and BDNF,”Science 247:1446-1451 (1990).
Chao, Moses V. et al., “Gene Transfer and Molecular Cloning of the Human NGF Receptor,”Science 232:518-521 (1986).
Headington, John T., “Transverse Microscopic Anatomy of the Human Scalp,”Arch. Dermatol. 120449-456 (1984).
Sperling, Leonard C., “Hair anatomy for the clinician,”Journal of the American Academy of D

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