Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-08-16
2011-08-16
Landsman, Robert (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S001100
Reexamination Certificate
active
07998932
ABSTRACT:
The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell adhesion to the extracellular matrix, endothelial cell apoptosis, and endothelial cell angiogenesis mediated by alpha-defensins.
REFERENCES:
Bdeir et al. Inhibition of neovascularization by alpha-defensins: a polential link between inflammation and angiogenesis, 2002, Blood, Nov. 16, vol. 100, Issue 11, Abstract No. 2673.
Chavakis et al., Regulation of neovascularization by human neurophil peptides (alpha-defensins): a link between inflammation and angiogenesis, 2004, FASEB Journal Express, online publication Jun. 18.
Chavakis et al.,Regulation of neovascularization by human neurophil peptides (alpha-defensins): a link between inflammation and angiogenesis, 2004, FASEB Journal Express, vol. 18, Issue 11, pp. 1306-1308.
Harwig et al., “Neutrophil Defensins: Purification, Characterization, and Antimicrobial Testing,”Methods in Enzymology, vol. 236, pp. 160-172, 1994.
Higazi et al., “Defensin Modulates Tissue-Type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells,”The Journal of Biological Chemistry, vol. 271, pp. 17650-17655, 1996.
Higazi et al., “Defensin Stimulates the Binding of Lipoprotein (a) to Human Vascular Endothelial and Smooth Muscle Cells,”Blood, vol. 12, pp. 4290-4298, 1997.
Zhou et al., “Impaired Angiogenesis, Delayed Wound Healing and Retarded Tumor Growth in Perlecan Heparan Sulfate-Deficient Mice,”Cancer Research, vol. 64, pp. 4699-4702, 2004.
Brodgen et al., “Defensins-induced adaptive immunity in mice and its potential in preventing periodontal disease,” Apr. 2003, vol. 18, Issue 2, pp. 95-99.
Chaly et al., 2000, European Cytokine Network, 11(2):257-66.
Bdeir et al., Inhibition of neovascularization by alpha defensins: a potential link between inflammation and angiogenesis, 2002,Blood, Nov. 16, vol. 100, Issue 11, Abstract No. 2673.
Chavakis et al., “Regulation of neovascularization by human neurophil peptides (alpha-defensins): a link between inflammation and angiogenesis”, 2004, FASEB Journal Express, online publication Jun. 18.
Chavakis et al., “Regulation of neovascuilarization by human neurophil peptides (alpha-defensins): a link between inflammation and angiogenesis,” 2004, FASEB Journal Express, vol. 18, Issue 11, pp. 1306-1308.
Bdeir Khalil
Chavakis Triantafylios
Cines Douglas
Preissner Klaus T.
Dang Ian
Landsman Robert
Riverside Law LLP
The Trustees of the University of Pennsylvania
LandOfFree
Inhibition of angiogenesis by neutrophil alpha-defensins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of angiogenesis by neutrophil alpha-defensins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of angiogenesis by neutrophil alpha-defensins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2771407