Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-07-20
2009-08-18
Landsman, Robert (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07576060
ABSTRACT:
The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell adhesion to the extracellular matrix, endothelial cell apoptosis, and endothelial cell angiogenesis.mediated by alpha-defensins.
REFERENCES:
Bdeir et al., Inhibition of neovascularization by alpha defensins: a potential link between inflammation and angiogenesis, 2002, Blood, Nov. 16, vol. 100, Issue, Abstract No. 2673.
Chavakis et al., Regulation of neovascularization by human neurophil peptides (alpha-defensisn): a link between inflammation and angiogenesis, 2004, FASEB Journal Express, online publication Jun. 18.
Chavakis et al.,Regulation of neovascularization by human neurophil peptides (alpha-defensins): a link between inflammation and angiogenesis, 2004, FASEB Journal Express, vol. 18, Issue 11, pp. 1306-1308.
Brodgen et al., Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease, Apr. 2003, vol. 18, Issue 2, pp. 95-99.
Chaly et al. European Cytokine Network, Jun. 2000, vol. 11, No. 2, pp. 257-266.
Harwig et al., “Neutrophil Defensins: Purification, Characterization, and Antimicrobial Testing,”Methods in Enzymology, vol. 236, pp. 160-172, 1994.
Higazi et al., “Defensin Modulates Tissue-Type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells,”The Journal of Biological Chemistry, vol. 271, pp. 17650-17655, 1996.
Higazi et al., “Defensin Stimulates the Binding of Lipoprotein (a) to Human Vascular Endothelial and Smooth Muscle Cells,”Blood, vol. 12, pp. 4290-4298, 1997.
Zhou et al., “Impaired Angiogenesis, Delayed Wound Healing and Retarded Tumor Growth in Perlecan Heparan Sulfate-Deficient Mice,”Cancer Research, vol 64, pp. 4699-4702, 2004.
Bdeir Khalil
Chavakis Triantafyllos
Cines Douglas
Preissner Klaus T.
Dang Ian
Drinker Dibble & Reath, LLP
Landsman Robert
The Trustees of the University of Pennsylvania
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