Inhibition of Aβ production by β-secretase BACE2

Details Inhibition of Aβ production by β-secretase BACE2 Inhibition of Aβ production by β-secretase BACE2

2007-02-27

2007-02-27

Gitomer, Ralph (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C435S024000, C435S069200

Reexamination Certificate

active

10749714

ABSTRACT:
The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases by reducing β-amyloid deposit formation.

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