Inhibition of 26S and 20S proteasome by indanones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 19, 514561, 514677, A61K 3800, A61K 31445, A61K 3195

Patent

active

06117887&

ABSTRACT:
This invention is novel indanone compositions useful for inhibiting cell proliferation disorders in mammals.

REFERENCES:
patent: 5409944 (1995-04-01), Black et al.
patent: 5457237 (1995-10-01), Dow
Coux et al., Annu. Rev. Biochem., vol. 65, pp. 801-847, Structure and Functions of the 20S and 26S Proteasomes (1996).
Lowe et al., Science, vol. 268, pp. 533-539, Research Article, Crystal Structure of the 20S Proteasome from the Archaeon T. acidophilum at 3.4 .ANG. Resolution (1995).
Dahlmann et al., FEBS Letters, vol. 251, No. 1,2, pp. 125-131, the Multicatalytic Proteinase (prosome) is Ubiquitous From Eukaryotes to Archaebacteria (1989).
Seemuller et al., FEBS Letters, vol. 359, pp. 173-178, The Proteasome From Thermoplasma Acidophilum is Neither a Cysteine Nor a Serine Protease (1995).
Orlowski, Biochemistry, vol. 29, No. 45, pp. 10289-10297, The Multicatalytic Proteinase Complex, a major Extralysosomal Proteolytic System (1990).
Orlowski et al., Biochemistry, vol. 32, pp. 1563-1572, Evidence for the Presence of Five Distinct Proteolytic Components in the Pituitary Multicatalytic Proteinase Complex. Properties of Two Components Cleaving Bonds on the Carboxyl Side of Branched Chain and Small Neutral Amino Acids (1993).
Vinitsky et al., Biochemistry, vol. 31, pp. 9421-9428, Inhibition of the Chymotrypsin-like Activity of the Pituitary Multicatalytic Proteinase Complex (1992).
Tsubuki et al., Biochemical and Biophysical Research Communications, vol. 196, No. 3, pp. 1195-1201, Purification and Characterization of a Z-Leu-Leu-Leu-MCA Degrading Protease Expected to Regulate Neurite Formation: A Novel Catalytic Activity in Proteasome (1993).
Rock et al., Cell, vol. 78, pp. 761-771, Inhibitors of the Proteasome Block the Degradation of Most Cell Proteins and the Generation of Peptides Presented on MHC Class I Molecules (1994).
Iqbal et al., J. Med. Chem., vol. 38, pp. 2276-2277, Potent Inhibitors of Proteasome (1995).
Iqbal et al., Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 3, pp. 287-290, Potent .varies.-Ketocarbonyl and Boronic Este Derived Inhibitors of Proteasome (1996).
Fenteany et al., Science, vol. 268, pp. 726-731, Inhibition of Proteasome activities and Subunit-Specific Amino-Terminal Threonine Modification by lactacystin (19950.
Omura et al., The Journal of Antibiotics, vol. 44, No. 1, pp. 117-118, Structure of Lactacystin, A New Microbial Metabolite Which Induces Differrentiation of Neuroblastoma Cells (1990).
Fenteany et al., Proc. Natl. Acad., Sci, USA, vol. 91, pp. 3358-3362, A.beta.-Lactone Related to Lactacystin Induces Neurite Outgrowth in a Neuroblastoma Cell Line and Inhibits Cell Cycle Progression in an Osteosarcoma Cell Line (1994).
Ciechanover, Cell, vol. 79, pp. 13-21, The Ubiquitin-Proteasome Proteolytic Pathway (1994).
Palombella et al., Cell, vol. 78, pp. 773-785, The Ubiquitin-Proteasome Pathway is Required for Processing the NF-.kappa.B1 Precursor Protein and the Activation of NF-.kappa.B (1994).
Ko et al., Genes & Development, vol. 10, pp. 1054-1072, p53: Puzzle and Paradigm (1996).
Oren, Seminars on Cancer Biology, vol. 5, pp. 221-227, Relationship of p53 to the Control of Apoptotic Cell Death (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibition of 26S and 20S proteasome by indanones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of 26S and 20S proteasome by indanones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of 26S and 20S proteasome by indanones will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-96536

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.