Inhibition adsorption of proteins on the liposome surface

Details Inhibition adsorption of proteins on the liposome surface Inhibition adsorption of proteins on the liposome surface

1996-07-09

1998-12-08

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 43, 264 46, 424450, 514832, A61K 9127, B01J 1322

Patent

active

058464581

ABSTRACT:
Agents for inhibiting adsorption of proteins on the liposome surface and liposomes which are agglutination-free by binding said inhibiting agent on the surface are disclosed. The above-mentioned inhibiting agents comprise a hydrophobic moiety and a hydrophilic macromolecular chain moiety. Adsorption of plasma proteins on the liposomes is inhibited due to the hydrophilic moiety exposed on the liposome surface with a result that agglutination of the liposomes in plasma is prevented. Therefore, there is no danger of embolism in blood vessels inhibiting blood flow when the liposomes are introduced into the living body. Accordingly, the liposomes are especially highly useful as artificial erythrocytes for which a large dose of liposomes is needed for administration.
Moreover, when liposomes are introduced into the living body, antibody protein (immunoglobulin) to the liposome which is an antigen will be adsorbed on the liposome to produce foreign body recognition in the phagocytes (macrophage) with a result that the liposome will be included in the macrophage and disappear within a short period of time. Thus, inhibition of the protein adsorption on liposome can delay disappearance of the liposome in plasma.
In addition, a method for preparing the above-described liposomes is disclosed.

REFERENCES:
patent: 4133874 (1979-01-01), Miller et al.
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4331654 (1982-05-01), Morris
patent: 4426330 (1984-01-01), Sears
patent: 4429008 (1984-01-01), Martin et al.
patent: 4480041 (1984-10-01), Myles et al.
patent: 4534899 (1985-08-01), Sears
patent: 4598051 (1986-07-01), Papahadjopoulos et al.
patent: 4775991 (1988-10-01), Staudinger et al.
patent: 4837028 (1989-06-01), Allen
patent: 4853228 (1989-08-01), Wallach et al.
patent: 4855090 (1989-08-01), Wallach
patent: 4885172 (1989-12-01), Bally et al.
patent: 4904479 (1990-02-01), Illum
patent: 4915951 (1990-04-01), Baldeschwieler et al.
patent: 4920016 (1990-04-01), Allen et al.
patent: 4921838 (1990-05-01), Catsimpoolas et al.
patent: 4931361 (1990-06-01), Baldeschwieler et al.
patent: 4948590 (1990-08-01), Hawrot et al.
patent: 4971803 (1990-11-01), Li et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5593622 (1997-01-01), Yoshioka et al.
Gregoriadis et al, Annals New York Academy of Sciences, 446, Targeting of Liposomes to Accessible Cells In Vivo, p. 319, 1985.
Japanese Patent Laid-Open Publn. No. 62-178521 (English translation) (1987).
Y. Inada et al, Chemistry Letters, 7, pp. 773-776, 1980.
Sax et al, eds., Hawley's Condensed Chemical Dictionary, 11th ed. (Van Nostrand Reinhold Company, New York), p. 936. (1987).

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