Inhibiting the development of tolerance to and/or dependence on

Details Inhibiting the development of tolerance to and/or dependence on Inhibiting the development of tolerance to and/or dependence on

1993-04-06

1994-06-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514216, 5142235, 5142255, 5142245, 514282, 5142312, 514289, 514812, 536 53, 536 551, A61K 3170, A61K 3155, A61K 3154, A61K 3144

Patent

active

053210123

ABSTRACT:
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.

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