Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-04-26
1997-08-05
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514216, 5142235, 5142255, 5142245, 514282, 5142312, 514270, 514304, 514305, 514306, 514307, 514812, A61K 3170, A61K 3155, A61K 3154, A61K 31535, A61K 3144, A61K 31445
Patent
active
056542810
ABSTRACT:
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl) -5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
REFERENCES:
patent: 4806543 (1989-02-01), Choi
patent: 5166207 (1992-11-01), Smith
patent: 5441982 (1995-08-01), Itzhak
Itzhak et al.,"Sensitization to the Toxic Effects of Cocaine in Mice is Associated with the Regulation of N-Methyl-D-Aspartate Receptors in the Cortex", The Journal of Pharmacology and Experimental Therapeutics, vol. 262, No. 2, pp. 464-470 (1992).
Lyle John W.
Mao Jianren
Mayer David J.
Price Donald D.
Criares Theodore J.
Virginia Commonwealth University
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