Inhibiting RNA expression by forming a pseudo-half-knot RNA at t

Details Inhibiting RNA expression by forming a pseudo-half-knot RNA at t Inhibiting RNA expression by forming a pseudo-half-knot RNA at t

1994-01-03

1996-04-30

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 536 245, 935 33, C07H 2104, C12Q 168, C12Q 170

Patent

active

055124380

ABSTRACT:
Compositions and methods for modulating the activity of RNA are provided. Oligonucleotides are hybridized with an RNA structure to form a stable heteroduplex so that the RNA is no longer recognized by its regulatory protein after oligonucleotide binding. Reactive moieties can be tethered to the oligonucleotide that enhance its activity. Antisense oligonucleotides directed against HIV TAR are provided.

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