Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2000-06-30
2003-04-22
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S047000, C424S070210, C424S074000, C424S746000, C435S419000, C435S430000, C435S431000, C514S844000
Reexamination Certificate
active
06551625
ABSTRACT:
CROSS-REFERENCE TO PRIORITY APPLICATION
This application claims priority under 35 U.S.C. §119 of FR-99/08569, filed Jul. 2, 1999, hereby expressly incorporated by reference.
BACKGROUND OF THE INVENTION
1. Technical Field of the Invention
The present inventions relates to novel hygienic/deodorant compositions comprising at least one extract of undifferentiated plant cells with the exception of cells from the genus Bellis, for inhibiting disagreeable or objectionable odors, especially body odors, and to the use of such novel compositions for the cosmetic applications indicated above.
2. Description of the Prior Art
The anatomy and physiology of human and animal skin vary from one part of the body to another. However, irrespective of the anatomical region, the skin contains sebaceous glands and sweat glands whose excretions contain, inter alia, water, amino acids, urea, electrolytes and/or specific fatty acids. Other than the fact that these excretions represent excellent nutrient media for the development of, principally bacterial, flora which colonizes the skin, their individual components, once in contact with the air, undergo chemical reactions, for example such as oxidation, which degrade them and promote formation of products responsible for body odors which occasionally may prove to be embarrassing.
Certain substances which are natural odor inhibitors (bactericidal and/or bacteriostatic) due to the partial degradation of the complex lipids secreted by the sweat glands are volatile and may be associated with a strong odor which it is customary to combat.
However, skin excretions are not the only factors responsible for body odor. The skin flora are themselves partly responsible therefor.
In cosmetics, it is well known to formulate deodorant products for topical application, these products containing active agents such as antiperspirants or bactericides to reduce or even prevent a generally unpleasant body odor.
Antiperspirant substances elicit the effect of limiting the flow of sweat. They are generally aluminum salts, which are firstly irritant to the skin and secondly reduce the flow of sweat by modifying the skin physiology, which is unsatisfactory.
By inhibiting the growth of the. skin flora responsible for body odor, bactericidal substrates present the drawback of not being active against the sweat odor already developed. These bactericidal products, of which the one most commonly used is triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol), are thus insufficiently effective over the long term.
Further, deodorants can modify the microflora, mainly towards Gram-negative bacteria, and consequently trigger infections.
Thus, serious need continues to exist for effective compounds and/or compositions for treating disagreeable/objectionable body odors which present no adverse side effects.
SUMMARY OF THE INVENTION
It has now surprisingly and unexpectedly been determined that extracts of undifferentiated plant cells can inhibit disagreeable/objectionable odors, particularly the odors associated with human sweat.
Briefly, thus, the present invention features novel hygienic/deodorant compositions comprising at least one extract of undifferentiated plant cells, with the exception of cells from the genus Bellis, such novel compositions being well suited for inhibiting odors.
According to the this invention, at least one extract of undifferentiated plant cells is employed to inhibit body odors and, even more especially, the odors due to animal or human sweat.
This invention preferably deodorizes human sweat.
DETAILED DESCRIPTION OF BEST MODE AND SPECIFIC/PREFERRED EMBODIMENTS OF THE INVENTION
More particularly according to the present invention, by the expression “undifferentiated plant cells” is intended any plant cell which has none of the characteristics of a particular specialization and which is capable of living by itself and independently of other cells.
Undifferentiated plant cells can be obtained from plant material derived from the whole plant or from a plant part such as the leaves, stalks, flowers, petals, roots, fruit, seed or anthers.
The undifferentiated plant cells are preferably obtained from leaves.
The undifferentiated plant cells which are employed according to the invention can be obtained from plants obtained by in vivo culturing or derived from in vitro culturing.
By the expression “in vivo culturing” is intended any culturing of conventional type, i.e., in soil in the open air or in a greenhouse, or, alternatively, without soil.
By the expression “in vitro culturing” is intended the set of techniques known to those skilled in the art which makes it possible to artificially obtain a plant or a part of a plant. The pressure of selection imposed by the physicochemical conditions during the growth of plant cells in vitro makes it possible to obtain a standardized plant material which is available throughout the year, unlike plants cultivated in vivo.
Undifferentiated plant cells obtained via in vitro culturing are preferably employed according to the invention.
The undifferentiated plant cells according to the invention may be obtained by any method known in the prior art. In this respect, exemplary are the methods described by E. F. George and P. D. Sherrington in
Plant Propagation by Tissue Culture,
handbook and directory of commercial laboratories (Exegetics Ltd. 1984).
The culture media which can be used according to the invention are those generally known to those skilled in the art. Examples are the Gamborg, Murashige-Skoog, Heller, White, etc. media. Complete descriptions of these media are contained in “Plant Culture Media: formulations and uses” by E. F. George, D. J. M. Puttock and H. J. George (Exegetics Ltd. 1987, volumes 1 & 2).
The undifferentiated plant cells are preferably prepared by culturing on Murashige-Skoog medium.
Any extraction technique known to those skilled in the art can be used to prepare the extract according to the invention.
Thus, the extracts according to the invention may be in any known form. Particularly exemplary are aqueous, alcoholic, in particular ethanolic, or aqueous/alcoholic extracts.
According to the invention, the extract is preferably an aqueous extract.
It is also envisaged to employ an extract prepared via the technique described in FR-95/02379, assigned to the assignee hereof.
Thus, in a first step, the plant material is ground in an aqueous solution under cold conditions, and in a second step the particles in suspension are removed from the aqueous solution derived from the first step. This aqueous solution corresponds to the extract.
The aqueous solution derived from the second step is optionally sterilized in a third step.
The extract can advantageously be lyophilized in a subsequent step.
The first step can be advantageously replaced with an operation of simple freezing of the plant tissues (for example at −20° C. or even at −180° C. in liquid nitrogen), followed by an aqueous extraction repeating the second and third steps described above.
The cold-temperature treatment allows the enzymatic activities to be frozen, and the sterilizing filtration avoids the degradation of the active agents by environmental microorganisms. Finally, the water vehicle is compatible with the ex vivo receptors and facilitates the cosmetic formulations.
It is known that plant extracts contain, other than proteases which can harm the quality of the extract, oxidases which are responsible, inter alia, for the oxidation of said extracts. In point of fact, such an oxidation imparts to the extracts a dark brown color and an acrid odor, thus rendering them unsuitable for use in cosmetics. Similarly, a lactase whose molecular weight is greater than 100,000 daltons is known, in particular.
Thus, the extract obtained can advantageously be fractionated by any known fractionation method for removing oxidases and in particular polyphenol oxidase. For example, the extract of the invention can be filtered through a dialysis membrane in order to remove the molecules with a molecular weight of greater than 100,000 daltons. It is also
Courbiere Christophe
Hilaire Pascal
Martin Richard
Burns Doane Swecker & Mathis L.L.P.
Societe l'Oreal S.A.
Srivastava Kailash C.
Tate Christopher R.
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