Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1989-04-11
1992-04-07
Saunders, David A.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436536, 436543, 436547, 436548, 436817, 530397, 530399, 530412, 530417, 530806, 530850, 5303892, 53038824, C07K 1514, G01N 33536
Patent
active
051028077
ABSTRACT:
A protein which satisfies all the biological criteria which are characteristic of inhibin has been isolated from a gonadal source. The purification and characterization of inhibin and the use of the purified material to raise antibodies, the use of inhibin and said antisera in a quantative radioimmunoassay, and applications in vitro and in vivo of inhibin and antibody to inhibin, are described.
There is provided a purified protein, inhibin, characterised in that
REFERENCES:
patent: 3984539 (1976-10-01), Khouw et al.
patent: 4624944 (1986-11-01), Li et al.
patent: 4737578 (1988-04-01), Evans et al.
patent: 4740587 (1988-04-01), Ling et al.
patent: 4798885 (1989-01-01), Mason et al.
W. J. Herbert, in D. M. Weir (ed.), Handbook of Experimental Immunology, 3rd Edition, Blackwell Scientific Publications, 1978, pp. A3.1-A3.15.
Robertson, D. M. et al. "Isolation of Inhibin from Bovine Follicule Fluid," Bio Bioph Res Comm; (126.1 (1985) pp. 220-226.
Miyamoto, K. et al., "Isolates of Porcine Follecular Fluid Inhibin of 32K Daltons", Bio Bioph Res Comm; 129:2 (1985) pp. 396-403.
Ling et al. "Isolation and Partial Characterization of M.sub.r 32000 Protein . . . Follicular Fluid", Proc Natl Acad. Sci 82 (1985) pp. 7217-7221.
Rivier, J. et al., "Purification and Partial Characterization of Inhibin from Porcine Follicular Fluid", Biochem and Bioph Res Comm pp. 120-127 (1987).
Mason, A. J. et al., "Complementary DNA Sequence of Ovarian Follicular Fluid Inhibin Show Precursor Stucture and Homology with Transforming Growth Factor-Beta", Letters to Nature pp. 659-663. (1985).
Fukuda, M. et al., "Isolation of Bovine Follicular Fluid Inhibin of About 32 KDa", Molecular and Cellular Endocrinology, 44: pp. 55-60 (1986).
Mason, A. J. et al. "Structure of Two Human Ovarian Inhibin", Biochem and Bioph Res Comm, pp. 957-964 (1986).
Forage, R. G. et al. "Cloning and Sequence Analysis of cDNA Species Coding for the Two Subuits of Bovine Follicular Fluid", Proc. Natl. Acad. Sci. USA pp. 3091-3095 (1986).
McLachlan, R. I. et al., "Plasma Inhibin Levels During Gonadotropin-Induced Ovarian Hyperstimulation of IVF": The Lancet, pp. 1233-1234 (1986).
Tsonis, C. G. et al., "Dual Gonodal Control of Follicle Stimulating Hormone", Nature, pp. 724-725 (1986).
de Kreiser, D. M. et al., "Control of FSH and LH Secretion", Monograph of Endocrinology pp. 12-43 (1983).
Au, C. L. et al., "Effects of Testosterone on Testicular Inhibin and Fluid Production in Intact and Hypophysectomized Adult Rats", J. Reprod. Fert. pp. 257-266 (1986).
Au, C. L. et al., "Relationship Between Testicular Inhibin Content and Serum FSH Concentrations in Rats After Bilateral Efferent Duct Ligation", J. Reprod. Fert. pp. 351-356 (1984).
Robertson, D. M. et al., "The Effects of Inhibin Purified from Bovine Follicular Fluid in Several In-Vitro Pituitary Cell Culture Systems", Molecular and Cellular Endocrinology, pp. 29-36 (1986).
de Kreiser, D. M. et al., "Fertility Regulation in the Male: Recent Developments", Recent Advances in Fertility Regulation, pp. 112-121 (1980).
de Kreiser, D. M., "Inhibin Becomes a Reality", Research in Reproduction pp. 1-4 (1986).
Robertson et al., "The Use of .sup.51 Cr for Assessing Cytoxicity in an In-Vitro Bioassay for Inhibin" Molecular and Cellular Endocrinology pp. 119-127 (1982).
Scott, R. S. et al., "The Specificity of Inhibin Bioassay Using Cultured Pituitary Cells", Molecular and Cellular Endocrinology, pp. 307-316 (1982).
Le Gac, F. et al., "Inhibin Production by Sertoli Cell Cultures," Molecular and Cellular Endocrinology pp. 487-498 (1982).
Baker, H. W. G., "Present Status of Research on Inhibin: An Appraisal", Clinical Reproduction and Fertility, pp. 161-174 (1983).
McLachlan, R. I. et al., "The Human Placenta: A Novel Source of Inhibin", Biophys. Biochem. Res. Comm. pp. 51-58 (1986).
de Kreiser, D. M., "The Testis, Reproduction in Mammals" pp. 76-90.
de Kreiser, D. M., "Morphology and Physiology of the Testis", Principles and Practice of Endocrinology and Metabolism pp. 928-937.
McLachlan, R. I. et al., "Circulating Immunoactive Inhibin in the Luteal Phase and Early Gestation of Women Undergoing Ovulation Induction", Fertility and Sterility pp. 001-005 (1987).
Biological Abstracts, vol. 79, No. 94-408, 1985.
Chemical Abstracts, vol. 94, No. 187299k, 1981.
Chemical Abstracts, vol. 98, No. 626 g, 1983.
Seidah, N. G., Arbatti, N. J. Rochemont, J. Sheth, A. R., and Chretien, M. Complete Amino Acid Sequence of Human Seminal Plasma Beta-Inhibin, FEBS Letters, 175 (1984), pp. 349-355.
Ross, G. T. and Vande Wiele, R. L., Frantz, A. G., The Ovaries and the Breasts, In: Textbook of Endocrinology (Williams, Ed.) (1981), pp. 355-411.
McLachlan, R. I., Robertson, D. M., Burger, H. G. and de Kretser D. M., The Radioimmunuassay of Bovine and Human Follicular Fluid, and "Serum Inhibin, Molecular and Cellular Endocrinology 46 (1986), pp. 175-185.
Briand, J. P., Muller, S., and Van Regcamortel, M.H.V., Synthetic Peptides as Antigens: Pitfalls of Conjugation Methods, J. Immunol. Methods 78 (1985), pp. 59-69.
de Jong, F. H., Jansen, E. H. J. M., Hermans, W. P., and van der Molen, H. J., Purification, Characterization and Physiological Significance of Inhibin from Ovarian Follicular Fluid. Adv. Biosci. 34 (1982), 73-84.
Sevier, E. D., David, G. S., Martinis, J., Desmond, W. J., Bartholomew, R. M., and Wang, R., Monoclonal Antibodies in Clinical Immunology, Clin. Chem. 27, (1981), pp. 1797-1806.
Dobos, M., Burger, H. G., Hearn, M. T. W., and Morgan, F. J., Isolation of Inhibin From Ovine Follicular Fluid Using Reversed-Phase Liquid Chromatography, Molecular and Cellular Endocrinology 31 (1983), pp. 187-198.
Franchimont, P., Verstraclen-Proyard, J., Hazee-Hargelstein, M. T.: Renard, C., Demoulin, A., Bourguignon, J. P., and Hustin, J., Inhibin: From Concept to Reality, Vitamins and Hormones, 37, (1979), pp. 243-302.
de Jong, F. H. and Robertson, D. M., Inhibin: 1985 Update on Action and Purification, Molecular and Cellular Endocrinology 42 (1985), pp. 95-103.
Astedt, B., Lecander, I., Brodin, T., Lundblad, A., and Low, K., Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator, Thrombosis and Haemostasis (1985, pp. 122-125).
Kopitar, M., Rozman, B., Babnik, J., Turk, V., Mullins, D. E., and Wun, T. C., Human Leukocyte Urokinase Inhibitor-Purification Characterization and Comparative Studies Against Different Plasminogen Activators, Thrombosis and Haemostatis 54 (1985) 750-755.
Begent, R. H. I., Green, A. I., Bagshawe, K. D., Jones, B. E. Keep, P. A., Scarle, F. Jewkes, R. F., Barrat, G. M., and Ryman, B. E., Liposomally Entrapped Second Antibody Improves Tumour Imaging with Radiolabelled (First) Antitumour Antibody, The Lancet, 2 (1982), pp. 739-741
Ellouz, F., Adam, A., Clorbaru, R. and Lederer, E. Minimal Structural Requirement for Adjuvant Activity of Bacterial Peptidoglycan Derivatives, Bioch, and Biophys. Res. Comm: 59 (1974), pp. 1317-1322.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Protein Measurement with the Folin Phenol Reagent, J. Biol. Chem. 193 (1951), pp. 265-275.
Bradford, M. M., A Rapid and Sensitive Method of the Quantitiation of Microgram Quantities of Protein, Utilizing the Principle of Protein Dye Binding, Analytical Biochem 72 (1976), pp. 248-254.
McCullagh, D. R., "Dual Endocrine Activity of the Testes," Science 76 (1932), 19-14 20.
de Jong, F. H., "Inhibin-Fact or Artifact," Molecular and Cellular Endocrinology 13 (1979), pp. 1-10.
Seidah, N. G., Ramasharma, K., Sairam, M., and Chretien, M., "Partial Amino Acid Sequence of a Human Seminal Plasma Peptide with Inhibin-like Activity," PEBS Letters 167 (1984), 98-102.
Sheth, A. R., Aranbatti, N., Carlquist, M., and Jornvall, H., "Characterization of a Polypeptide from Human Seminal Plasma with Inhibin (Inhibition of a FSH Secretion)-like Activity," FEBS Letters 165 (1984), 11-15.
Beksac, M., Khan, S., Eliasson, R., Skakkelback, N., Sheth, A., and Diczlalusy, E., "Evidence for the Prostatic Origin of Immunoreactive Inhibin-like Material in Human
Burger Henry G.
de Kretser David M.
Findlay John K.
Forage Robert G.
Hearn Milton T. W.
Biotechnology Australia Pty Ltd.
Monash Medical Centre
Monash University
Saunders David A.
St. Vincent's Institute of Medical Research
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