Inhaler system for targeted maximum drug-aerosol delivery

Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C128S200240, C128S200140, C128S203120, C128S203150

Reexamination Certificate

active

07900625

ABSTRACT:
A smart inhaler system comprising an inhaler device for directed aerosol delivery facilitated by an adaptive nozzle and a mechanism for inhalation waveform modulation is provided. Methods of using the smart inhaler system for delivering an active agent to a target area of a lung of a subject are further provided.

REFERENCES:
patent: 2064314 (1936-12-01), Morin
patent: 2456451 (1948-12-01), Seaver
patent: 4095596 (1978-06-01), Grayson
patent: 5040527 (1991-08-01), Larson et al.
patent: 5355872 (1994-10-01), Riggs et al.
patent: 5363842 (1994-11-01), Mishelevich et al.
patent: 5404871 (1995-04-01), Goodman et al.
patent: 5437267 (1995-08-01), Weinstein et al.
patent: 5474058 (1995-12-01), Lix
patent: 5487378 (1996-01-01), Robertson et al.
patent: 5843050 (1998-12-01), Jones et al.
patent: 5899201 (1999-05-01), Schultz et al.
patent: 5906202 (1999-05-01), Schuster et al.
patent: 6014972 (2000-01-01), Sladek
patent: 6041777 (2000-03-01), Faithfull et al.
patent: 6190326 (2001-02-01), Mckinnon et al.
patent: 6202642 (2001-03-01), McKinnon et al.
patent: 6230703 (2001-05-01), Bono
patent: 6325475 (2001-12-01), Hayes et al.
patent: 6363932 (2002-04-01), Forchione et al.
patent: 6422236 (2002-07-01), Nilsson et al.
patent: 6443146 (2002-09-01), Voges
patent: 6539937 (2003-04-01), Haveri et al.
patent: 6682716 (2004-01-01), Hodges et al.
patent: 6708688 (2004-03-01), Rubin et al.
patent: 6748945 (2004-06-01), Grychowski et al.
patent: 6830046 (2004-12-01), Blakley et al.
patent: 7007689 (2006-03-01), Burns
patent: 7028686 (2006-04-01), Gonda et al.
patent: 7036500 (2006-05-01), Niles et al.
patent: 7072499 (2006-07-01), Deschamps
patent: 7073499 (2006-07-01), Reinhold et al.
patent: 7077125 (2006-07-01), Scheuch
patent: 7080643 (2006-07-01), Grychowski
patent: 7090830 (2006-08-01), Hale et al.
patent: 7131441 (2006-11-01), Keller et al.
patent: 7316360 (2008-01-01), Patel et al.
patent: 2002/0000225 (2002-01-01), Schuler et al.
patent: 2002/0062062 (2002-05-01), Belson et al.
patent: 2003/0089368 (2003-05-01), Zhao
patent: 2003/0168057 (2003-09-01), Snyder et al.
patent: 2004/0050385 (2004-03-01), Bonney et al.
patent: 2004/0097805 (2004-05-01), Verard et al.
patent: 2004/0133231 (2004-07-01), Maitland et al.
patent: 2005/0028814 (2005-02-01), Robertson et al.
patent: 2006/0137681 (2006-06-01), Von Hollen et al.
patent: 2006/0149350 (2006-07-01), Patel et al.
patent: 2006/0191534 (2006-08-01), Hickey et al.
patent: 2007/0016069 (2007-01-01), Grunwald
patent: 2007/0151562 (2007-07-01), Jones et al.
patent: 2007/0156042 (2007-07-01), Unal
patent: 2007/0219480 (2007-09-01), Kamen et al.
patent: 2007/0235029 (2007-10-01), Zhu et al.
patent: 2008/0245363 (2008-10-01), Korevaar et al.
patent: 2008/0262467 (2008-10-01), Humphrey et al.
patent: WO2008/048234 (2008-04-01), None
Zhang et al.Comparison of micro- and nano-size particle depositions in a human upper airway model Journalof Aerosol Science, vol. 36, (2005), pp. 211-233.
Zhang et al.Gas-solid two-phase flow in a triple bifurcation lung airway model International Journal of Multiphase Flow, vol. 28, (2002), pp. 1021-1046.
Kleinstreuer et al.Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors Journal of Biochemical Engineering, vol. 125, (2003), pp. 197-206.
Joseph et al. MEMS in the Medical World.Sensors Magazine[online] (Apr. 1997) <http://archives.sensorsmag.com/articles/0497/medical/main.shtml>.
Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration corresponding to International Application No. PCT/US06/33596 dated Jul. 28, 2008.
Thorne. Inhalation toxicology models of endotoxin- and bioaerosol-induced inflammation,Toxicology, vol. 152, pp. 13-23 (2002).
Zhang et al., Computational Analysis of Micron-particle Deposition in a Human Triple Bifurcation Airway Model.Computer Methods in Biomechanics and Biomedical Engineering, vol. 5, No. 2, pp. 135-147 (2002).
Kleinstreuer et al., “A new methodology for targeting drug-microspheres in the human respiratory system,” International Journal of Heat & Mass Transfer. vol. 51 pp. 5578-5589 (2008).
Notification Concerning Transmittal of International Preliminary Report on Patentability (Chapter I of the Patent Cooperation Treaty) corresponding to International Application No. PCT/US2006/033596 dated Sep. 4, 2008.
Ariel, “Treatment of Inoperable Primary Pancreatic and Liver Cancer by the Intra-Arterial Administration of Radioactive Isotopes (Y99Radiating Microspheres),” Annals of Surgery. vol. 162, No. 2 pp. 267-278 (1965).
Asgharian, B., and Anjilvel, S., “A Monte Carlo Calculation of the Deposition Efficiency of Inhaled Particles in Lower Airways,” J. Aerosol. Sci. vol. 25, No. 4 pp. 711-721 (1994).
Asgharian, B., and Anjilvel, S., “The Effect of Fiber Inertia on Its Orientation in a Shear Flow with Application to Lung Dosimetry,” Aerosol Science and Technology. vol. 23, No. 3 pp. 282-290 (1995).
Atassi et al., “Multimodality Imaging Following90Y Radio-embolization: A Comprehensive Review and Pictorial Essay,” Radiographics. vol. 28, No. 1 pp. 81-99 (2008).
Balásházy et al., “Computation of Local Enhancement Factors for the Quantification of Particle Deposition Patterns in Airway Bifurcations,” J. Aerosol. Sci. vol. 30, No. 2 pp. 185- 203 (1999).
Balásházy et al., “Local particle deposition patterns may play a key role in the development of lung cancer,” J. Appl. Physiol. vol. 94 pp. 1719-1725 (2003).
Benaïssa et al., “Modelling evaporation of multicomponent fuel droplets under ambient temperature conditions,” Journal of the Institute of Energy. vol. 75, No. 502 pp. 19-26.
Berlemont et al., “Heat and mass transfer coupling between vaporizing droplets and turbulence using a Lagrangian approach,” Int. J. Heat Mass Transfer. vol. 38, No. 16 pp. 3023-3034 (1995).
Bowes, S.M., III, and Swift, D.L., “Deposition of Inhaled Particles in the Oral Airway During Oronasal Breathing,” Aerosol Science and Technology. vol. 11, No. 2 pp. 157-167 (1989).
Breedis, C., and Young, G., “The Blood Supply of Neoplasms in the Liver,” Am. J. Pathol. pp. 969-985 (1954).
Broday, D.M., and Georgopoulos, P.G., “Growth and Deposition of Hygroscopic Particulate Matter in the Human Lungs,” Aerosol Science and Technology. vol. 34 pp. 144-159 (2001).
Buchanan et al., “Rheological effects on pulsatile hemodynamics in a stenosed tube,” Computers & Fluids. vol. 29 pp. 695-724 (2000).
Bushi et al., “Hemodynamic Evaluation of Embolic Trajectory in an Arterial Bifurcation: An In-Vitro Experimental Model,” Stroke. vol. 36 pp. 2696-2700 (2005).
Campbell et al., “Analysis of the distribution of intra-arterial microspheres in human liver following hepatic yttrium-90 microsphere therapy,” Phys. Med. Biol. vol. 45 pp. 1023-1033 (2000).
Cheng et al. , “Dose estimate of inhaled hafnium tritide using the ICRP 66 lung model,” Health Physics. vol. 82 pp. 817-824 (2002).
Fan et al., “Gass Collection Efficiency and Entrance Flow Effect of an Annular Diffusion Denuder,” Aerosol Science and Technology. vol. 25, No. 2 pp. 113-120 (1996).
Fujioka et al., “Oscillatory Flow and Gas Transport Through a Symmetrical Bifurcation,” Journal of Biomechanical Engineering. vol. 123 pp. 145-153 (2001).
Gemci et al., “A Numerical and Experimental Study of Spray Dynamics in a Simple Throat Model,” Aerosol Science and Technology. vol. 36 pp. 18-38 (2002).
Gosman, A.D., Ioannides, E., “Aspects of computer simulation of liquid-fueled combustors,” Journal of Energy. vol. 7, No. 6 pp. 482-490 (1983) [ABSTRACT].
Grotberg, “Pulmonary Flow and Transport Phenomena,” Annu. Rev. Fluid Mech. vol. 26 pp. 529-571 (1994).
Grotberg, “Respiratory Fluid Mechanics and Transport Processes,”

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhaler system for targeted maximum drug-aerosol delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhaler system for targeted maximum drug-aerosol delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhaler system for targeted maximum drug-aerosol delivery will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2680513

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.