Inhalation exposure apparatus

Surgery – Liquid medicament atomizer or sprayer

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Details

12820019, 12820329, 12820525, 128910, A61M 1500

Patent

active

045208085

ABSTRACT:
An inhalation apparatus for exposing small laboratory animals, e.g., rats, to a test atmosphere in such a manner that the animals are exposed to a uniform concentration of the test atmosphere containing substantially no exhaled materials.
The apparatus comprises, e.g., an animal holding tube capable of positioning the nose of an animal at a fixed point within the tube. The tube is provided with a test atmosphere inlet means located in the vicinity of the nose and an exhaust outlet such that the test atmosphere can be inhaled by the animal then exhausted rearward of the nose of the animal.
A plurality of these animal holding tubes can be combined by connecting their inlet to a first plenum duct that is in communication with a source of the test atmosphere and connecting their outlet to a second plenum duct for exhausting substantially all exhaled materials and excess test atmosphere.

REFERENCES:
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patent: 3230577 (1966-01-01), Hughes
patent: 3915165 (1975-10-01), Rambosek et al.
patent: 4332244 (1982-06-01), Levy et al.
Schmidtke, "Removal of Inhaled Radioactive Yttrium by the Use of Diethylenetriamine-Pentaacetic Acid (DTPA)", Health Physics, Pergamon Press, 1964, vol. 10, pp. 1235-1241, Printed in Northern Ireland.
Lie, "Deposition and Retention of .sup.137 C.sub.s in the Rat Following Inhalation of the Chloride and the Nitrate", Health Physics, Pergamon Press, 1964, vol. 10, pp. 1071-1076, Printed in Northern Ireland.
Raabe et al., "An Improved System for Exposure of Beagle Dogs to Radioactive Aerosols", Inhalation Toxicology Research Inst. Annual Report, 1972-1973, LF-46, UC-48, Dec. 1973, pp. 10-15.
LaBauve et al., "Cytogenetic and Other Biological Effects of .sup.239 PuO.sub.2 Inhaled by the Rhesus Monkey", Radiat. Res. 82, 310-335 (1980).
Boecker et al., "A Canine Inhalation Exposure Apparatus Utilizing a Whole Body Plethysmograph", Health Physics, Pergamon Press, 1964, vol. 10, pp. 1077-1089.
Craig et al., "Deposition, Translocation and Effects of Transuranic Particles Inhaled by Experimental Animals", Biology Department, Battelle, Pacific Northwest Labs., Richmond, WA 99352, Airbourne Radioactivity (No. 710001), ANS La Grange Park, IL, 1978.

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