Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1993-04-23
1994-09-20
Asher, Kimberly L.
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820321, 12820323, 604 57, 222162, A61M 1508, A61M 1600, A61M 3100, B67D 564
Patent
active
053479998
DESCRIPTION:
BRIEF SUMMARY
The invention relates to an inhalation device free from propellent gas, having a supply of a medicinal substance which is to be inhaled, a manually operable metering device for removing a given dose of the medicinal substance for the particular inhalation process and with a mouthpiece for actively breathing in and an air space for distributing the particular dose of medicinal substance in the air stream.
An inhalation device of this kind is known from DE 35 35 561 A1.
In this known inhalation device, below the storage container and parallel to the mouthpiece is a rotary charging valve which has wells (metering chambers) for measuring out the medicinal substance. If the wells are turned towards the storage container they are automatically filled. If, as a result of a 180.degree. rotation of the charging valve, the filled well is turned towards the air chamber of the mouthpiece, the dose of powder falls out of the well, as a result of gravity, with the aid of a jogging mechanism, into a cavity in the air channel and from there is inhaled into the lungs or bronchial tubes of the patient by means of active breathing in. The air channel has a constriction which is intended to promote the mixing of the air with the medicinal substance by turbulence.
This known device, like numerous other known devices, is based on the principle of storing the medicinal substance in powder form in a storage container and measuring out the dose by filling a metering chamber. The contents of the metering chamber are then expelled by gravity or with the aid of the active breathing in of the patient, possibly with a mechanical aid.
An inhalation device using this method of metering has the disadvantage that the dosage to be inhaled is not sufficiently reproducible and is not satisfactorily dispersed.
The aim of the invention is to start with a propellent-free inhalation device of the kind described hereinbefore and design it so that the dose breathed in is highly reproducible and is well dispersed.
According to the invention, this problem is solved by providing a holder in which the supply of medicinal substance, solidified in a given geometric structure, is contained, and associated with this holder, as a metering device, is an abrasion device for mechanically abrading the given dose.
Thus, in the propellent-free inhalation device according to the invention, the medicinal substance is stored not in powder form but in solid form; the required dose is only powdered immediately before the inhalation process by a mechanical operation. This mechanical operation, i.e. the abrasion of the medicinal substance, can be made relatively accurate and reproducible, so that the dose of powdered medicinal substance breathed in is also highly reproducible.
The solidified supply of medicinal substance may be prepared, for example, by mixing micronised active substance (particle size<10 .mu.m) with a physiologically harmless excipient or carrier, such as lactose, and compressing the mixture to form a body which has a constant cross-section in the direction of its longitudinal axis. The shape of the cross-section may otherwise take a variety of forms, with the result that the body may be, for example, a cube, cylinder or prism. To ensure that the abrasion is carried out as uniformly as possible, a device may be provided which causes the body to rotate about its longitudinal axis, possibly so that the body is rotated through 25.degree. to 90.degree., e.g. 55.degree., on each actuation of the device.
The invention is explained more fully with reference to some embodiments by way of example shown in the drawings. Characterising features of the invention will become apparent.
In the drawings:
FIG. 1 is an embodiment by way of example of the propellent-free inhalation device according to the invention in the unused position,
FIG. 2 shows the inhalation device according to FIG. 1 in the primed position, i.e. ready for inhaling,
FIG. 3 shows a section along the line A--A in FIG. 1, illustrating another embodiment.
The propellent-free inhalation device show
REFERENCES:
patent: 2587215 (1952-02-01), Priestly
patent: 3456645 (1969-07-01), Brock
patent: 3921637 (1975-11-01), Bennie et al.
patent: 5176132 (1993-01-01), Drought et al.
Poss Gerhard
Wittekind Jurgen
Asher Kimberly L.
Boehringer Ingelheim KG
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