Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1993-05-11
1995-04-25
Burr, Edgar S.
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820014, 12820023, A61M 1500
Patent
active
054089948
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to inhalation activatable devices for the administration of medicaments for inhalation therapy.
BACKGROUND
Inhalation activatable dispensers for use with aerosol container assemblies are known, their general purpose being to afford proper co-ordination of the dispensing of a dose of medicament with the inhalation of the patient thereby allowing the maximum proportion of the dose of medicament to be drawn into the patient's bronchial passages. Examples of such dispensers are described in British Patent Specification Nos. 1,269,554, 1,335,378, 1,392,192 and 2,061,116 and U.S. Pat. Nos. 3,187,748, 3,456,644, 3,456,645, 3,456,646, 3,565,070, 3,598,294, 3,814,297, 3,605,738, 3,732,864, 3,636,949 and 3,789,843 and German Patent No. 3,040,641.
European Patent No. 147028 discloses an inhalation activatable dispenser for use with an aerosol container in which a latch mechanism releasing vane is pivotally mounted in an air passage between an aerosol outlet valve and a mouthpiece, which latch mechanism cannot be released if force to activate the dispenser is not applied before a patient inhales.
The dispenser generally comprises a housing having a mouthpiece and an air passage therethrough terminating at the mouthpiece, the housing being adapted to receive an aerosol container and having a support block with a socket adapted to receive the stem of the valve of the aerosol container and a through orifice communicating between the socket and the air passage, and latch means having parts movable between an engaged position in which movement of the container and the support block toward each other upon the application of a force to bias the container and the support block toward each other is prevented and a release position in which movement of the container and the support block toward each other in response to said force is permitted causing the stem to move to its inner discharge position, the latch means comprising a vane mounted on the housing in the air passageway between the orifice and the mouthpiece for movement toward the mouthpiece under the influence of inhalation through the mouthpiece to release the latch means in which the vane moves toward the mouthpiece from a blocking to a non-blocking position with respect to the passageway in response to inhaling at the mouthpiece and releases the latch means only during the application of said force to bias the container and support block toward each other.
Co-pending International Patent Application No. PCT/US90/02412 (Publication No. WO90/13328) discloses a dry powder inhalation device comprising a housing defining a chamber in communication with a patient port in the form of a mouthpiece or nasal adaptor, and an elongate carrier bearing a powdered medicament, the device being constructed and arranged such that areas of predetermined size of the elongate carrier may sequentially be exposed within the chamber, the device comprising one or more air inlets such that when a patient inhales through the patient port an air flow is established from the air inlet(s) to the patient port through the chamber such that particles of the powdered medicament of respirable size from said exposed area of the elongate carrier are entrained within the air flow.
The dry powder inhaler is capable of delivering multiple, uniform doses of a medicament to a patient. The device is simple to operate and does not require the patient to insert capsules of medicament or rely upon a separate reservoir of medicament in order to load the device for use. The medicament is generally preloaded on an elongate carrier, sections of which are sequentially exposed in the chamber for dispensing the medicament. The elongate carrier is preferably in the form of a tape having an array of depressions or microdimples holding micronised medicament and may be conveniently loaded on a spool (in a similar manner to a photographic film) or in a cassette (in a similar manner to an audio cassette). A preferred carrier is disclosed in European Patent Publication No. 0
REFERENCES:
patent: 3456644 (1969-07-01), Thiel
patent: 3456645 (1969-07-01), Brock
patent: 3565070 (1971-02-01), Hanson
patent: 3598294 (1971-08-01), Hedrick et al.
patent: 3789843 (1974-02-01), Armstrong et al.
patent: 4664107 (1987-05-01), Wass
patent: 4803978 (1989-02-01), Johnson, IV et al.
patent: 5031610 (1991-07-01), Armstrong et al.
patent: 5119806 (1992-06-01), Palson et al.
Baum Eric A.
Hodson Peter D.
Law Brian R.
Wass Anthony C. L.
Burr Edgar S.
Griswold Gary L.
Hulse Dale E.
Kirn Walter N.
Lewis Aaron J.
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