Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1996-06-19
1999-11-16
Weiss, John G.
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820312, 12820014, 12820321, 12820021, A61M 1600
Patent
active
059838930
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to an inhalation device for inhalation of a pharmaceutically active substance from a reservoir in an inhaler comprising an inhalation channel with an air inlet and an air outlet, said device comprising a dispersing chamber having an air inlet and an air outlet into which the active substance may be sucked from said reservoir through the air outlet and means for allowing a user to inhale the active substance from said dispersing chamber, said dispersing chamber being defined by at least a first non-movable element and a second movable element, said second element being substantially cylinder-formed, said first element being arranged in said second element whereby a vacuum or negative pressure is created in said dispersing chamber when said first and second elements are moved in relation to each other.
The inhalation device according to the invention is preferably a breath-actuated dry-powder inhaler, containing multiple doses of a medicament containing an active substance, the inhaler having maneuvering unit for loading one dose of the medicament to a dosing unit and providing said dose in a position for inhalation. An inhaler of the prescribed type is described in EP-A-0 069 715 and EP-A-0 237 507.
The device according to the invention is especially designed for patients who are not able to actively inhale or who are not able to create the inhalation flow necessary to release and lift the dose of the substance into the inhalation channel and to the lungs when using a breath-actuated inhaler.
BACKGROUND OF THE INVENTION
Inhalable pharmaceutically active substances are generally used for treatment of diseases in the bronchial and pulmonary area, such as asthma and chronic bronchitis. Various embodiments of inhalation devices or apparatus are used for the purpose. The function of these known devices depends on the creation of an airflow through the inhalation device caused by an inhalation by the patient. The airflow causes active substance to moved from a release position into the airflow in which it is dispersed. A specially advantageous inhaler of the above mentioned type is the dry-powder, breath-actuated multidose inhaler TURBUHALER.RTM., schematically described in the above mentioned EP-patents.
Some patients such as small children and elderly people with diseases in the bronchial area are not able to use a breath-actuated inhaler as it might be hard or even impossible for these patients to achieve the necessary inhalation flow and these patients are today reduced to the use of inhalers using pressurized gas, i.e. freon. Such inhalers suffer from many known disadvantages, such as unwanted side effects.
Furthermore, it is presently a problem to administer an Inhalable substance to an asthma patient who is anesthetized during an operation and the patient can not actively inhale. For many asthmatic patients the administration of asthma pharmaceuticals during an operation is vital.
PRIOR ART
In order to facilitate the inhalation of pharmaceutically active substances being administered by the use of pressurized metered dose inhalers, so called PMDIs, it is known to provide expansion chambers into which the substance, with the pressurized gas, is dispersed. These devices are generally called spacers and a typical spacer is known from GB 1 565 029.
Furthermore, inhalation devices including dispersion chambers have been developed for breath-actuated dry-powder inhalers of the above mentioned type. Such an inhalation device is described in EP-A-0 548 152. This device is however bulky and contains several mechanical parts which makes the device complicated and expensive to produce and to use. The reliability is not very high due to the complexibility of the device.
SUMMARY OF THE INVENTION
The present invention relates to an inhalation device of the above mentioned type which can be used by patients having reduced ability to create an inhalation flow necessary to lift the dose from the release position into the inhalation channel when using a breath-actuated inhaler, and whi
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Astra Aktiebolag
Srivastava V.
Weiss John G.
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