Surgery – Liquid medicament atomizer or sprayer – Pre-pressurized container holding medicament
Patent
1995-02-15
1996-04-30
Burr, Edgar S.
Surgery
Liquid medicament atomizer or sprayer
Pre-pressurized container holding medicament
12820312, A61M 1100
Patent
active
055115403
DESCRIPTION:
BRIEF SUMMARY
FILED OF THE INVENTION
This invention relates to an inhalation device for administration of medicament in the form of aerosolised solid particles or droplets of liquid or suspension. In particular the invention relates to such devices which are actuated to dispense medicament in response to the patient's inspiration.
BACKGROUND
Asthma and other respiratory diseases have long been treated by the inhalation of appropriate medicament. For many years the two most widely used and convenient choices of treatment have been the inhalation of medicament from a drug solution or suspension in a metered dose pressurised inhaler (MDI), or inhalation of powdered drug generally admixed with an excipient, from a dry powder inhaler (DPI).
Inhalation activatable dispensers for use with aerosol containers which contain medicament and are pressurised with liquid propellants and are equipped with a motoring valve through which a plurality of metered doses may be dispensed are known, their general purpose being to afford proper co-ordination of the dispensing of a dose of medicament with the inhalation of the patient thereby allowing the maximum proportion of the dose of medicament to be drawn into the patient's bronchial passages. Examples of such dispensers are described in British Patent Specification Nos. 269,554, 1,335,378; 1,392,192, 2,061,116 and 2,240,930 U.S. Pat. Nos. 3,456,644, 3,456,645, 3,456,646, 3,565,070, 3,598,294, 3,814,297, 3,605,738, 3,732,864, 3,636,949, 3,789,843 and 3,187,748 and German Patent No. 3,040,641.
European Patent No. 147028 discloses an inhalation activatable dispenser for use with an aerosol container in which a latch mechanism releasing vane is pivotally mounted in an air passage between an aerosol outlet valve and a mouthpiece, which latch mechanism cannot be released if force to activate the dispenser is not applied before a patient inhales.
The dispenser generally comprises a housing having a mouthpiece and an air passage therethrough terminating at the mouthpiece, the housing being adapted to receive an aerosol container and having a support block with a socket adapted to receive the stem of the valve of the aerosol container and a through orifice communicating between the socket and the air passage, and latch means having parts movable between an engaged position in which movement of the container and the support block toward each other upon the application of a force to bias the container and the support block toward each other is prevented and a release position in which movement of the container and the support block toward each other in response to said force is permitted causing the stem to move to its inner discharge position, the latch means comprising a vane mounted on the housing in the air passageway between the orifice and the mouthpiece for movement toward the mouthpiece under the influence of inhalation through the mouthpiece to release the latch means in which the vane moves toward the mouthpiece from a blocking to a non-blocking position with respect to the passageway in response to inhaling at the mouthpiece and releases the latch means only during the application of said force to bias the container and support block toward each other.
This inhalation device has been received favourably by patients and doctors since it not only overcomes the hand-lung co-ordination problem but it does so at a very low triggering flow-rate (approximately 30 liters/minute) essentially silently, and with a very compact design barely larger than a standard inhaler.
Many inhalation activatable dispensers utilise a spring to bias the container relative to the valve stem and ultimately move the container relative to the valve stem to fire the device upon inhalation. Generally the spring acts upon the base of the container and is compressed prior to patient inhalation by a priming force generated by operation of a priming lever which may be a separate lever or connected to a pivoting mouthpiece cover. In some arrangements, after activation of the device and removal of the priming force the va
REFERENCES:
patent: 3187748 (1965-06-01), Mitchell et al.
patent: 3456644 (1969-07-01), Thiel
patent: 3456645 (1969-07-01), Brock
patent: 3456646 (1969-07-01), Phillips et al.
patent: 3565070 (1971-02-01), Hanson et al.
patent: 3598294 (1971-08-01), Hedrick et al.
patent: 3605738 (1971-09-01), Ciranna
patent: 3636949 (1972-01-01), Kropp
patent: 3732864 (1973-05-01), Thompson et al.
patent: 3789843 (1974-02-01), Armstrong et al.
patent: 3814297 (1974-06-01), Warren
patent: 5060643 (1991-10-01), Rich et al.
U.K. Search Report dated Sep. 16, 1992.
PCT International Search Report dated Dec. 7, 1993.
PCT Written Opinion dated Apr. 12, 1994.
PCT International Preliminary Examination Report dated Aug. 24, 1994.
Troitsky, A. (ed.), "Machine Elements: A Textbook," Foreign Languages Publishing House (Moscow: 1963) pp. 545-553.
Sweet's 1969 Mechanical File, Alco Forge and Spring, Inc. Catalog, pp. 1-7.
Bryant Andrew M.
Wass Anthony C. L.
Zilligan Guenter M.
Burr Edgar S.
Griswold Gary L.
Hulse Dale E.
Kirn Walter N.
Minnesota Mining and Manufacturing Company
LandOfFree
Inhalation device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhalation device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhalation device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-622295