Ingestible polymeric phosphonium salts, composition thereof and

Details Ingestible polymeric phosphonium salts, composition thereof and Ingestible polymeric phosphonium salts, composition thereof and

1992-03-23

1995-06-27

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Digestive system regulator containing solid synthetic...

424 781, 521 38, 526277, A61K 3174, A61K 3180

Patent

active

054277779

ABSTRACT:
Novel ingestible polymeric phosphonium salts have the formula: ##STR1## wherein P' represents a cross-linked and non-digestible polymer backbone; R is a lower alkyl radical; X.sup.- is a pharmaceutically acceptable anion; n, n.sub.1 and n.sub.2 are, independently, integers varying from 0 to 6 inclusive, with the proviso that when m.sub.1 .gtoreq.1, n.sub.2 .gtoreq.1; and o.sub.1, o.sub.2, p.sub.1 p.sub.2, q.sub.1 and q.sub.2 are, independently, integers varying from 1 to 6 inclusive. The polymeric phosphonium salts of the invention are highly efficient sorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.

REFERENCES:
patent: 2781290 (1957-02-01), Martin et al.
patent: 4446284 (1984-05-01), Parker
patent: 4774262 (1988-09-01), Blanquet et al.
patent: 4775651 (1988-10-01), Tachikawa et al.
patent: 4996047 (1991-02-01), Kelleher et al.
patent: 5114709 (1992-05-01), St. Pierre et al.

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