Ingestible polymeric amines for the lowering of blood cholestero

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Ion exchange resin

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424 781, 424 7816, A61K 3174

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053667247

ABSTRACT:
The invention is concerned with novel ingestible polymeric amines in linear or branched form of the formula: ##STR1## and their pharmaceutically acceptable salts of the formulae: ##STR2## wherein P represents a hydrophilic, cross-linked and digestable polymer backbone; R is a hydrogen atom or a lower alkyl radical; X.sup.- is a pharmaceutically acceptable anion; m is an integer varying from 1 to 10 inclusive; and n, o and p are, independently, integers varying from 2 to 12 inclusive. The polymeric amines of the invention are highly efficient adsorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.

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Winne, D. and Gorig, H., "Appearance of .sup.14 C-Polyethylene Glycol 4000 in Intestinal Venous Blood: Influence of Osmolarity and laxatives, Effect on Net Water Flux Determination", Naunyn-Schmirdeberg's Arch. Pharmacol. 321:149-156 (1982).
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