Ingestible [hydrophobic] polymeric amines useful for lowering bl

Details Ingestible [hydrophobic] polymeric amines useful for lowering bl Ingestible [hydrophobic] polymeric amines useful for lowering bl

1991-03-25

1994-12-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Ion exchange resin

424 7816, A61K 3174, L08F11208

Patent

active

053744225

ABSTRACT:
The invention is concerned with novel ingestible cross-linked homopolymers having functional groups consisting of linear or branched amines, of the formula: ##STR1## and their pharmaceutically acceptable salts of the formulae: ##STR2## wherein P(or POLYMER .parallel.-) represents a hydrophobic, cross-linked and non-digestible homopolymer backbone; R is a hydrogen atom or a lower alkyl radical; X.sup.- is a pharmaceutically acceptable anion; m is an integer varying from 1 to 6 inclusive; and n, o and p are, independently, integers varying from 2 to 12 inclusive. The amine functionalized and cross-linked homopolymers of the invention are highly efficient adsorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.

REFERENCES:
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patent: 3787474 (1974-01-01), Daniels et al.
patent: 4060678 (1977-11-01), Steepler
patent: 4082701 (1978-04-01), Fries et al.
patent: 4211765 (1980-07-01), Johnson et al.
patent: 4311799 (1982-01-01), Miyake et al.
patent: 5236701 (1993-08-01), St. Pierre et al.

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