Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Ion exchange resin
Patent
1989-07-19
1993-08-17
Michl, Paul R.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Ion exchange resin
424 781, 424 7811, 5253294, A61K 3174
Patent
active
052367010
ABSTRACT:
The invention is concerned with novel ingestible cross-linked homopolymers having functional groups consisting of linear or branched amines, of the formula: ##STR1## and their pharmaceutically acceptable salts of the formulae: ##STR2## wherein P represents a hydrophilic, cross-linked and non-digestible homopolymer backbone; R is a hydrogen atom or a lower alkyl radical; X.sup.- is a pharmaceutically acceptable anion; m is an integer varying from 1 to 10 inclusive; and n, o and p are, independently, integers varying from 2 to 12 inclusive. The amine functionalized and cross-linked homopolymers of the invention are highly efficient adsorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.
REFERENCES:
patent: 3308020 (1967-03-01), Wolfe et al.
patent: 3733400 (1973-05-01), Queuille et al.
patent: 3787474 (1974-01-01), Daniels et al.
patent: 4082701 (1978-04-01), Fries et al.
patent: 4115550 (1978-09-01), Fields et al.
patent: 4211765 (1980-07-01), Johnson et al.
patent: 5114709 (1992-05-01), Pierre et al.
"Concise Encyclopedia of Polymer Science & Engineering", Ed., Kroschwitz, J. I., J. Wiley & Sons, Publisher, N.Y., pp. 213-217.
Wallace, J. S., & Morrow, C. J., "Biocatalytic Synthesis of Polymers.II--Preparation of [AA-BB].sub.x Polyesters by Porcine Pancreatic Lipase Catalized Transesterification in Anhydrous, Low Polarity Organic Solvents", J.Polymer.Sci: Part A:Polymer.Chem.27:3271-3284(1989).
"The Merck Index", Ed., Windholz, M., Merck & Co., Inc. Publisher, Rathway, N.J.,(1983),p. 410.
Winne, D., & Gorig, H., "Appearance of .sup.14 C-Polyethylene Glycol 4000 in Intestinal Venous Blood:Influence of Osmolarity and Laxatives, Effect on Net Water Flux Determination", Archives of Pharmacology. 321:149-156(1982).
Brown George R.
St. Pierre Leon E.
Wu Gaoming
Amzel Viviana
Lowchol Scientific Inc.
Michl Paul R.
Yoon Tae H.
LandOfFree
Ingestible hydrophilic polymeric amines useful for lowering bloo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ingestible hydrophilic polymeric amines useful for lowering bloo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ingestible hydrophilic polymeric amines useful for lowering bloo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2242378