Infusion of neutrophil precursors for treatment of neutropenia

Details Infusion of neutrophil precursors for treatment of neutropenia Infusion of neutrophil precursors for treatment of neutropenia

1998-08-27

2000-01-04

Lankford, Jr., Leon B.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424 9371, 435325, C12N 500

Patent

active

060106972

ABSTRACT:
The invention provides a method of treating a patient having a reduced population of neutrophils following a myeloablative cancer treatment such as high dose chemotherapy. Following myeloablative therapy, a cell composition of at least 25% neutrophil precursors, i.e. promyelocytes, myelocytes, and metamyelocytes, is administered to the patient. Thereafter, the neutrophil precursors differentiate rapidly in vivo to replenish the supply of mature neutrophils for fighting infection. The method is used to reduce the neutropenic window between the time of myeloablative therapy and the time required for infused stem cells to proliferate and differentiate into mature neutrophils.

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