Influenza vaccines

Details Influenza vaccines Influenza vaccines

1974-11-29

1976-11-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

195 11, 195 12, 195 13, A61K 3918, C12K 500, C12K 700

Patent

active

039911799

ABSTRACT:
A recombinant influenza virus strain derived from (a) an over-attenuated influenza A strain which has been passaged solely in chicken egg cultures, manifests a relatively high yield of virus in such cultures and has an increased capacity for plaque formation on calf kidney cells and (b) a virulent influenza A strain which manifests a relatively low culture yield of virus and is substantially free from contaminating mammalian viruses; a method of manufacturing the recombinant strain and a vaccine incorporating it.
The virulent strain is preferably one fairly recently isolated at the time of manufacture of the vaccine. The over-attenuated strain should have sufficient antigenic distinction between it and the virulent strain and have a proven safety record.

REFERENCES:
kilbourne, Science, vol. 160 (Apr. 1968) pp. 74 & 75.
Beare et al. - The Lancet, Dec. 11, 1971, pp. 1271-1273.
Kilbourne, Hospital Practice, Oct. 1971, pp. 103-106, 111, 112 and 114.

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