Influenza vaccine production in liquid cell culture

Details Influenza vaccine production in liquid cell culture Influenza vaccine production in liquid cell culture

1982-09-29

1985-02-19

Marantz, Sidney

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435236, 435237, 435238, 435239, A61K 3912, C12N 700, C12N 702, C12N 704

Patent

active

045005133

ABSTRACT:
Infectivity and replication of influenza viruses in successive numbers of cells of the same liquid cell culture is assured by including a protein hydrolyzing enzyme in the culture during virus incubation. Technique overcomes "one-step growth cycle" of virus and allows commercial influenza vaccine production from liquid cell cultures instead of from more costly embryonated chicken eggs. Resulting vaccine is thus substantially free of egg proteins.

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Klenk et al., Virology 68, 426-439 (1975).
Lazarowitz et al., (I), Virology 68, 440-454 (1975).
Lazarowitz et al., II, Virology 52, 199-212 (1973).

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