Influenza vaccine containing purified neuraminidase antigen and

Drug – bio-affecting and body treating compositions – Lymphokine

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A61K 3918

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active

040297632

ABSTRACT:
An influenza vaccine is disclosed which comprises, as an active ingredient, neuraminidase antigen which has been isolated from an antigenically functional virus and has substantial cross-reactivity with the influenza virus against which the vaccine is to be effective. The neuraminidase antigen can be derived from a virus antigenically representative of the contemporary or prevalent influenza virus subtype of interest, e.g., H3N2, the Hong Kong variant of influenza.

REFERENCES:
schulman et al., J. Virol., vol. 2, pp. 778-786, Aug. 1968.
Chemical Abstracts (1), vol. 78, entry 93005d, 1973.
Chemical Abstracts (2), vol. 80, entry 81006h, 1974.
Dowdle, New England J. Med., vol. 286, pp. 1360-1361, June 1972.
Kilbourne, Hospital Practice, Oct. 1971, pp. 103-114.
Kilbourne et al., J. Virology, vol. 2, pp. 281-288, Apr. 1968.
The Lancet, Aug. 5, 1972, pp. 264 & 265.
Rott et al., J. Gen. Virol., Vol. 22, pages 35-41, 1974.
Schild, J. Hyg. Camb., vol. 67, pp. 353-365, June 1969.

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