Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2005-05-17
2005-05-17
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C422S051000, C422S068100, C422S082010, C422S082050, C422S082110, C435S007100, C435S007900, C435S007920, C435S174000, C435S235100, C435S287100, C435S287200, C435S288700, C435S808000, C435S817000, C436S056000, C436S128000, C436S164000, C436S172000, C436S518000, C436S524000, C436S529000, C436S805000, C436S811000, C436S815000, C356S073100, C356S432000, C356S445000, C356S928000
Reexamination Certificate
active
06893814
ABSTRACT:
A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.
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Sackmann, “Supported Membranes: Scientific and Practical Applications,” Science, vol. 271, pp. 43-48, Jan. 5, 1996.
Sudbeck et al., “Guanidinobenzoic Acid Inhibitors of Influenza Virus Neuraminidase,” J. Mol. Biol., vol. 267, pp. 584-594, 1997.
Schmidt Jurgen G.
Silks, III Louis A.
Song Xuedong
Swanson Basil I.
Unkefer Clifford
Cottrell Bruce H.
Le Long V.
Padmanabhan Kartic
The Regents of the University of California
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