Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1984-10-22
1988-11-08
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
424 89, 4352402, C12N 708, A61K 39145
Patent
active
047834110
ABSTRACT:
A method for preparing vaccines against influenza-A, and vaccines prepared thereby. Influenza-A virus is subjected to at least two passages in goldfish cell cultures, resulting in attenuated virus having reduced infectivity and somewhat altered antigenic characteristics relative to the starting virus, but which when used as a vaccine to innoculate mammalian species confers immunity. Immunization tests conducted in mice showed the vaccine to be effective.
REFERENCES:
patent: 3950511 (1976-04-01), Gaudry
patent: 3953592 (1976-04-01), Peetermans
patent: 3991179 (1976-11-01), Beare
patent: 4219543 (1980-08-01), Hartmann
patent: 4278662 (1981-07-01), Lobmann
patent: 4318903 (1982-03-01), Lobmann
patent: 4338296 (1982-07-01), Lobmann
Berry, E. S. et al., Journal of Fish Diseases 6(6):501-510 (1983), cited in Biosis Abstract 84:247368.
Shea, T. B. et al., Applied Environmental Microbiology 47(2):250-252 (1984), cited in Biosis Abstract 84:271531.
Computer printout from a background search. The titles and abstracts are considered self-explanatory.
Abstract No. 83 from the 34th Annual Meeting of the Tissue Culture Association held Jun. 12-16, 1983. This discloses a new continuous cell line from goldfish. Journal of the Tissue Culture Assoc. 19(3):255 (1983).
Abstract No. 92 from the 34th Annual Meeting of the Tissue Culture Association held Jun. 12-16, 1983. This discloses a serum-free medium for fish cell cultures. Journal of the Tissue Culture Assoc. 19(3), 257 (1983).
Winton et al, Isolation of a New Reovirus from Chum Salmon in Japan, Fish Pathology, 15, 155-162 (1981). This reference deals with isolation of a fish virus from salmon.
Abstract from the Annual Meeting of the American Society of Microbiology, 1975, Growth of Human Polio Virus Type I in Fish cells, by Sinclair, et al. The title is self-explanatory. p. 210, abstract Q36.
K. B. Tan, Enhancement of simian virus 40 uptake by permissive, semipermissive and non-permissive cells, published in Cytobios, 20, 143-149 (1978?). This reference deals with a monkey virus.
Migus and Dobos, Effect of Ribavirin on the Replication of Infectious Pancreatic Necrosis Virus in Fish Cell Cultures, J. Gen. Virol., 47, 47-57 (1980). This deals with a fish virus.
Meyers, A Reo-like Virus Isolated from Juvenile American Oysters, J. Gen. Virol., 43, 203-212 (1979). This deals with a virus from oysters.
Wharton, Ellender, Middlebrooks, and Stocks, Fish Cell Culture: Characteristics of a Cell Line from the Silver Perch, In Vitro, 13, 389-397 (1977). This reference deals with a cell line from Perch.
Middlebrooks, Ellender, and Wharton, In Vitro, 15, 109-111 (1979). This deals with a cell line from the spotted weakfish.
Berry, Shea and Gabliks, Two Iridovirus Isolates from Carassium Auratus, J. Fish Diseases, 6, 501-510 (1983). This deals with the isolation of two viruses from goldfish.
Berry, Goldfish Virus-1: Characterization, Relationship to Goldfish Virus-2, & the Effects of Temperature & Host Cell on In Vitro Pathogenesis. This is a dissertation submitted in partial fulfillment of the requirements for Dr. of Philosophy degree in Biology at Northwestern Univ. (1983), and deals with 2 goldfish viruses.
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