Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds

Details Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds

1984-05-04

1985-12-24

Evans, J. E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260404, 260413, C11C 100, C09F 508, C09F 700

Patent

active

045605149

ABSTRACT:
The present invention provides novel lipoxins A and B and a method of stimulating with lipoxin A compounds and attenuating with lipoxin B compounds the activation of neutrophils by exposure to an effective concentration of lipoxins or a derivative thereof. Also provided in the present disclosure are methods and compositions for preventing or treating inflammation, inflammatory responses, or inflammatory diseases and conditions in mammals, including humans, by administration of lipoxin B compounds. Lipoxins are novel trihydroxy-tetraene derivatives of arachadonic acid related to the leukotrienes.

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