Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-22
2005-03-22
Leffers, Gerry (Department: 1636)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S023400, C435S069100, C435S320100, C435S455000, C435S325000
Reexamination Certificate
active
06870044
ABSTRACT:
The present invention relates to the field of the regulation of the expression of genes and is based in particular on the use of constructs which make it possible to activate the transcription of a transgene in cells, tissues or organs under inflammatory conditions. The promoters of the invention preferably comprise a) a PPAR response element and b) the whole or part of the promoter of the PLA2sIIA gene. The invention also relates to vectors, cells and compositions comprising these promoters, as well as their use for the regulation of the expression of genes in vitro, ex vivo or in vivo.
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Cyril Couturier et al, Interleukin 1B Induces Type 2-secreted Phospholipase A2 Gene in Vascular Smooth Muscle Cells by a Nuclear Factor kB and Peroxisome Proliferator-activated Receptor-mediated Process, vol. 274, No. 33, Aug. 13, pp. 23085-23093, 1999.*
C. Couturier et al., Interleukin 1Beta Induces Type II-secreted Phospholipase A2 Gene in Vascular Smooth Muscle Cells by a Nuclear Factor KappaB and Peroxisome Proliferator-activated Receptor-mediated Process, J. Biol. Chem. 274(33):23085-23093 (1999).
C. Juge-Aubry et al., DNA Binding Properties of Peroxisome Proliferator-Activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements., J. Biol. Chem. 272(40):25252-25259 (1997).
K. Mukhopadhyay et al., Use of a New Rat Chondrosarcoma Cell line to Delineate a 119-Base Pair Chondrocyte-speciic Enhancer Element and to Define Active Promoter Segments in the Mouse Pro-alpha1(II) Collagen Gene, J. Biol. Chem. 270(46):27711-27719 (1995).
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Berenbaum Francis
Bereziat Gilbert
Massaad Charbel
Olivier Jean-Luc
Salvat Colette
Leffers Gerry
Universite Pierre et Marie Curie
Young & Thompson
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