Inferferon-.alpha.-induced protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435325, 4352523, 43525233, 4353201, 4351721, 536 231, 536 235, 536 242, 536 243, 530350, C12P 2106, C07H 2104

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058342354

ABSTRACT:
The present invention is directed to an isolated nucleic acid molecule encoding an interferon-.alpha.-induced protein, particularly the protein designated p36. Expression vectors and host cells comprising the nucleic acid molecule are also provided, as well as methods for increasing or decreasing the expression of the interferon-.alpha.-induced protein in host cells. DNA oligomers and antibodies specific for interferon-.alpha.-induced protein are provided, each of which can be used to detect interferon-.alpha.-induced protein in a sample. Methods for diagnosing immunodeficiency and autoimmune disease in an individual and methods for detecting the presence or past existence of lupus inclusions or interferon-.alpha. in a sample are also provided.

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