Infective protein delivery system

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

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435325, 435366, 4353723, 4353722, 4353201, 435363, 4352351, 536 235, 536 231, 536 2352, 424 9321, 424 932, 935 9, 935 10, 935 22, 935 32, 935 71, 935 64, 935 60, 935 57, 935 70, C12N 508, C12N 1519, C12N 1523

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058495860

ABSTRACT:
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.

REFERENCES:
patent: 4405712 (1983-09-01), Vande Woude et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4603112 (1986-07-01), Paoletti et al.
patent: 4650764 (1987-03-01), Temin et al.
patent: 4663281 (1987-05-01), Gillies et al.
patent: 4677063 (1987-06-01), Mark et al.
patent: 4677064 (1987-06-01), Mark et al.
patent: 4708818 (1987-11-01), Montanier et al.
patent: 4725669 (1988-02-01), Essex et al.
patent: 4752565 (1988-06-01), Folks et al.
patent: 4769330 (1988-09-01), Paoletti et al.
patent: 4847201 (1989-07-01), Kaswasaki et al.
patent: 4861719 (1989-08-01), Miller
patent: 4868116 (1989-09-01), Morgan et al.
patent: 4868119 (1989-09-01), Clark et al.
patent: 4879226 (1989-11-01), Wallace et al.
patent: 4894439 (1990-01-01), Dorin et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 4980289 (1990-12-01), Temin et al.
patent: 4990455 (1991-02-01), Yamagishi et al.
patent: 5028420 (1991-07-01), Masegi et al.
patent: 5081021 (1992-01-01), Mizuno et al.
patent: 5091309 (1992-02-01), Schesinger et al.
patent: 5206352 (1993-04-01), Robinson et al.
patent: 5246924 (1993-09-01), Fox et al.
patent: 5262309 (1993-11-01), Nakamura et al.
patent: 5288852 (1994-02-01), Yamada et al.
patent: 5304489 (1994-04-01), Rosen
patent: 5306631 (1994-04-01), Harrison et al.
patent: 5324655 (1994-06-01), Kriegler et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5487984 (1996-01-01), Allet et al.
patent: 5604293 (1997-02-01), Fiddes et al.
Stein (ed.) 1993, in: Internal Medicine, 4th edition, Mosby Year Book, pp. 699-715.
Rennie et al. (eds.) 1996, Scientific American 275(3): 126-132.
Watson et al. 1987, in: Molecular Biology Of The Gene, fourth edition, Benjamin/Cummings Publishing Company, Menlo Park, CA, p. 313.
Culver et al. 1988, J. Cell Biochem. Suppl. 12B: 171, abstract H105.
Ledley et al., "Retroviral Mediated Gene Transfer of Human Phenylalanine Hydroxylase Into NIH 3T3 and Hepatoma Cells," Proc. Nat'l Acad. Sci. USA, 83:409-413 (1986).
Maxwell et al., "Regulated Expression of a Transfected Toxin Gene," J. Cell. Biochem., Supplement 10D, p. 39 (Mar. 30, 1986) (Abstract N93).
Maxwell et al., "Regulated Expression of a Diphtheria Toxin A-Chain Gene Transfected into Human Cells: Possible Strategy for Inducing Cancer Cell Suicide," Cancer Res., 46:4660-4664 (Sep., 1986).
Rein et al., "Myristylation Site in Pr65.sup.gag Is Essential For Virus Particle Formation By Moloney Murine Leukemia Virus," Proc. Nat'l acad. Sci., USA, 83:7246-7250 (Oct., 1986).
Maxwell et al., "HTLV-Regulated Expression of a Transfected Diptheria Toxin Gene," J. Cell. Biol., Supplement 11D, p. 314, p. 67 (Mar. 29, 1987) (Abstract).
Harrison et al., "Toward HIV-Regulated Expression of a Diptheria Toxin A Gene In Transfected Cells," J. Cell Biol., Supplement 13B, p. 302 (Jan. 31, 1989) (Abstract G418).
Klein et al., "Separation and Characteristics of Tumor-Infiltrating Lymphocytes In Man," In: Contemporary Topics In Immunobiology, vol. 10, Witz and Manna, Jr., (Eds.), Plenum Press, New York, pp. 79-107 (1980).
Vose et al., "Separation of Tumor And Host Cell Populations from Human Neoplasms," In: Cancer Cell Organelles, Reid et al., (Eds.), Chinchester, Ellis Harwood Ltd., pp. 45-56 (1982).
Rosenberg et al., "A New Approach To the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes," Science, 223:1318-1321 (1986).
Spiess et al., "In Vivo Antitumor Activity of Tumor-Infiltrating Lymphocytes Expanded In Recombinant Interleukin-2," JNCI, 79:1067-1075 (Nov., 1987).
Muul et al., "Identification of Specific Cytolytic Immune Responses Against Autologous Tumor In Humans Bearing Malignant Melanoma," J. Immunol. 138:989-995 (1987).
Kurnick, "Functional Characterization of T Lymphocytes Propagated From Human Lung Carcinomas," Clin. Immunol. Immunopath., 38:367-80 (1986).
Rabinowich et al., "A Functional Analysis of Mononuclear Cells Infiltrating Into Tumors: Lysis of Autologous Human Tumor Cells By Cultured Infiltrating Lymphocytes," Cancer Res., 47:173-177 (1987).
Miescher et al., "Clonal and Frequency Analyses of Tumor-Infiltrating T Lymphocytes From Human Solid Tumors," J. Immunol., 138:4004-4011 (1987).
Topalian et al., "Expansion of Human Tumor Infiltrating Lymphocytes For Use in Immunotherapy Trials," J. Immunol. Methods, 102:127-141 (1987).
Belldegrun et al., "Interleukin 2 Expanded Tumor-Infiltrating Lymphocytes in Human Renal Cell Cancer: Isolation, Characterization, and Antitumor Ativity," Cancer Res., 48:206-214 (1988).
Buchan et al., "Interleukin-1 and Tumor Necrosis Factor mRNA Expression in Rheumatoid Arthritis: Prolonged Production of IL-1.alpha.," Clin. Exp. Immunol., 73:449-455 (1988).
Altmann et al., "Contransfection of ICAM-1 and HLA-DR Reconstitutes Human Antigen-Presenting Cell Function in Mouse L Cells," Nature, 338:512-514 (1989).
Anderson et al., "Gene Expression in Implanted Rat Hepatocytes Following Retroviral-Mediated Gene Transfer," Som. Cell and Mol. Genetics, 15:215-227 (1989).
Anderson, W.F., "Prospects for Human Gene Therapy," Science, 226:401-409 (1984).
Armentano et al., "Effect of Internal Viral Sequences on the Utility of Retroviral Vectors," J. Virology, 61:1647-1650 (1987).
Arnold et al., "Vaccine Development of Aids Through Molecular Surgery of a Human Common Cold Virus Surface," J. Cell. Biochem., L401:145 (1990).
Barnd et al., "Specific, Major Histocompatibility Complex-Unrestricted Recognition of Tumor-Associated Mucins By Human Cytotoxic T Cells," Proc. Nat'l Acad. Sci., USA, 86:7159-7163 (1989).
Berkner, K.L., "Development of Adenovirus Vectors for the Expression of Heterologous Genes," BioTechniques, 6:616-629 (1988).
Bernards et al., "Effective Tumor Immunotherapy Directed Against an Oncogene-Encoded Product Using a Vaccinia Virus Vector," Proc. Nat'l Acad. Sci., USA, 84:6854-6858 (1987).
Bernards et al., "N-myc Amplification Causes Down-Modulation of MHC Class I Antigen Expression in Neuroblastoma," Cell, 47:667-674 (1986).
Bolognesi et al., "Prospects of Treatment of Human Retrovirus-Associated Diseases," Cancer Research, Supplement, 45:4700s-4705s (1985).
Braciale et al., "Antigen Presentation Pathways to Class I and Class II of MHC-Restricted T Lymphocytes," Immunology Reviews, 98:95-114 (1987).
Bubenik et al., "Local Administration of Cells Containing an Inserted IL-2 Gene and Producing IL-2 Inhibits Growth to Human Tumors in nu
u Mice," Immunology Letters, 19:279-282 (1988).
Carey, J., "Human Gene Therapy: After a Lot of Looking, Now the Leap," Business Week, Science & Technology, pp. 133 & 136 (May 1, 1989).
Carr et al., "Genetic Transformation of Murine Bone Marrow Cells to Methotrexate Resistance," Blood, 62(1):180-185 (1983).
Cepko, C., "Retrovirus Vectors and Their Applications in Neurobiology," Neuron, 1:345-353 (1988).
Chakrabarti et al., "Expression of the HTLV-III Envelope Gene by a Recombinant Vaccinia Virus," Nature, 320:535-537 (1986).
Chan et al., "Mammalian Sarcoma-Leukemia Viruses. I. Infection of Feline, Bovine, and Human Cell Cultures With Snyder-Theilen Feline Sarcoma Virus," J. Nat'l Cancer Inst., 52(2):473-481 (1974).
Cline et al., "Gene Transfer in Intact Animals," Nature, 284:422-425 (1980).
Collins et al., "Transfer of Functional EGF Receptors to an IL3-Dependent Cell Line," J. Cell. Physiology, 137:293-298 (1988).
Cone et al., "HLA-DR Gene Expression in a Proliferating Human Thyroid Cell Clone (12S)" Endocrinology, 123(4):2067-2074 (1988).
Cortes et al., "Successful Immunotherapy in a Murine Metastasizing Fibrosarcoma Model," J. Surg. Onco., 25:289-295 (1984).
Crowley et al., "Generation of Human Autologous Melanoma-specific Cytotoxic T-Cells Using HLA-A2-matched Allogeneic Melanomas," Cancer Research, 50:492-498 (1990).
Culliton, B.J., "Designing Cells to Deliver Drugs," Sci

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