Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-02-25
2008-12-02
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S235100, C435S320100, C435S325000, C514S04400A
Reexamination Certificate
active
07459163
ABSTRACT:
A vaccine for West Nile virus that protects a subject against West Nile infection comprising an a pharmaceutically acceptable carrier and a therapeutically effective dose of an infectious agent selected from the group consisting of: a live attenuated infectious (+) RNA virus designated as WN1415, a vector comprising infectious DNA encoding an infectious (+) RNA molecule encoding the West Nile virus, and the West Nile (+) RNA virus designated as WN956D117B3 (GenBank #M12294).
REFERENCES:
Pugachev et al., “New developments in flavivirus vaccines with special attention to yellow fever,” Curr Opin Infect Dis 18:387-394 (2005).
Drebot et al., “West Nile Virus: Update for family physicians,” Can Fam Physician 51:1094-1099 (2005).
Lodish et al. “Molecular Cell Biology,” Second Printing, Scientific American Book, pp. 120-121 (1995).
Shi et al., “Infectious cDNA Clone of the Epidemic West Nile Virus from New York City,” Journal of Virology, vol. 76, No. 12 (pp. 5847-5856) (2002).
Lustig et al (Viral Immunology 13:401-410, 2000).
Yamschikov et al (Virology 281:294-304, 2001).
Yamschikov et al (Virology 272-280, 2001).
Yamshchikov, V.F., Wengler, G., Perelygin, A.a., Brinton, M.A., Compans, R.W., 2001. An infectious clone of the West Nile flavivirus. Virology 281 (2), 294-304.
Yamshchikov, V.F., Mishin, V. P., Cominelli, F., 2001. A new strategy in design of +RNA virus infectious clones enabling their stable propagation inE. coli. Virology 281, 272.
Yamshchikov, G., Borisevich, V., Seregin, A., Chaporgina, E., Mishina M., Mishin, V., Wai Kwok, C., Yamshchikov, V.F., 2004. An attenuated West Nile prototype virus is highly immunogenic and protects against the deadly NY99 strain: a candidate for live WN vaccine development. Virology 330, 304-312.
Mishin, V.P., Cominelli, F., Yamshchikov, V.F., 2001. A ‘minimal’ approach in design of flavivirus infectious DNA. Virus Research 81, 113-123.
Mosher Mary E
Stinson Morrison & Hecker LLP
University of Kansas
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