Infectious clone of human parvovirus B19 and methods

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

Reexamination Certificate

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C435S239000, C435S320100, C435S325000, C536S023720

Reexamination Certificate

active

07598071

ABSTRACT:
The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.

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