Infectious bovine viral diarrhea virus clone

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023720, C424S218100, C424S093600, C435S320100

Reexamination Certificate

active

07135561

ABSTRACT:
The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

REFERENCES:
patent: 6001613 (1999-12-01), Donis et al.
patent: 1013757 (2000-06-01), None
patent: WO-9964604 (1999-12-01), None
patent: WO 01/39801 (2001-06-01), None
Sequence alignment provided of SEQ ID No. 1 with GenEmbl database accession No. BVU18059, submitted Dec. 7, 1995.
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Meyer, Christiane; Recovery of Virulent and RNase-Negative Attenuated Type 2 Bovine Viral Diarrhea Viruses from Infectious cDNA Clones; (2002) 8494-8503; vol. 76; No. 16.
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van Gennip, H.G.P. et al; Recovery of infectious clasiical swine fever virus (CSFV) from full-length genomic cDNA clones by a swine kidney cell line expressing bacteriophage T7 RNA polymerase: Journal of Virological Methods (1999) 117-128; vol. 78.
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Racaniello, V.R. et al; Cloned Poliovirus Complimentary DNA Is Infections in Mammalian Cells; Science, 1981;214:916-919.
Carman, S. et al: Severe acute bovine viral diarrhea in Ontario, 1993-1995; J. Vet. Diagn Invest., 1998, 10:27-35.
The copending applications cited below are brought to the Examiner's attention but are not conceded to be prior art.
Elbers, K. et al: Safe Attenuated Bovine Viral Diarrhea Viruses For Use In Pregnant Cows, U.S. Appl. No. 09/706,649, filed Nov. 6, 2000.
Meyers, G.: Attenuated pestiviruses, U.S. Appl. No. 09/325,542, filed Apr. 6, 1999.
Julia F. Ridpath et al; The Genomic Sequence of a Virulent Bovine Viral Diarrhea Virus (BVDV) from the Type 2 Genotype: Detection of a Large Genomic Insertion in a Noncytopathic BVDV; Virology (1995) vol. 212 pp. 39-46; Virology Cattle Research National Animal Disease Center, Iowa.
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Beate M. Kummerer et al; Correlation between Point Mutations in NS2 and the Viability and Cytopathogenicity of Bovine Viral Diarrhea Virus Strain Oregon Analyzed with an Infections cDNA Clone: Journal of Virology Jan. 2000 vol. 74 No. 1 p. 390-400; American Society for Microbiology.
Gregor Meyers et al; Recovery of Cytopathogenic and Noncytopathogenic Bovine Viral Diarrhea Viruses from cDNA Constructs; Journal of Virology Dec. 1996 vol. 70 No. 12 p. 8606-8613; American Society of Microbiology.
Ventzislav B. Vassilev et al; Authentic and Chimeric Full-Length Genomic cDNA Clones of Bovine Viral Diarrhea Virus that Yield Infectious Transcriptst; Journal of Virology Jan. 1997 vol. 71 No. 1 p. 471-478: American Society for Microbiology.
Database Accession No. AF145967; XP002251610.
Copy of International Search Report for Reference PCT/EP 02/09925.
Constans, Aileen; Recent Developments in RT-PCR Technology Move Reverse Transcription in the right direction; The Scientist-Reverse Psychology 14[17]; 29, Sep. 4, 2000 pp. 1-4.
van der Poel, W.H.M.; Experimental Reproduction of Respiratory Disease in Calves with Non-Cell-Culture-Passaged Bovine respiratory Synctial Virus, The Veterinary Quarterly, vol. 18, No. 3, Sep. 1996—XP 009041333, pp. 81-86.

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